The article discusses the potential of microfluidic diagnostic technologies to improve global public health, particularly in developing countries. These technologies offer miniaturization and integration of complex functions, making sophisticated diagnostic tools more accessible and portable. Microfluidic systems can process small volumes of complex fluids efficiently and accurately, without requiring expert operators, making them ideal for point-of-care (POC) medical diagnostics. The development of microfluidic diagnostics has been boosted by funding from organizations like DARPA, which has supported the creation of robust medical technologies suitable for resource-limited environments. The article highlights the challenges and opportunities in designing microfluidic diagnostic systems for the developing world, including the need for low-cost, user-friendly, and reliable devices. It also outlines the current state of microfluidic diagnostics, such as lateral flow strip tests, and the future prospects of microfluidic technologies in addressing global health issues, particularly in the context of infectious diseases and tropical diseases. The authors emphasize the importance of collaboration between diagnostic developers and local communities to ensure the successful adoption and sustainability of these technologies.The article discusses the potential of microfluidic diagnostic technologies to improve global public health, particularly in developing countries. These technologies offer miniaturization and integration of complex functions, making sophisticated diagnostic tools more accessible and portable. Microfluidic systems can process small volumes of complex fluids efficiently and accurately, without requiring expert operators, making them ideal for point-of-care (POC) medical diagnostics. The development of microfluidic diagnostics has been boosted by funding from organizations like DARPA, which has supported the creation of robust medical technologies suitable for resource-limited environments. The article highlights the challenges and opportunities in designing microfluidic diagnostic systems for the developing world, including the need for low-cost, user-friendly, and reliable devices. It also outlines the current state of microfluidic diagnostics, such as lateral flow strip tests, and the future prospects of microfluidic technologies in addressing global health issues, particularly in the context of infectious diseases and tropical diseases. The authors emphasize the importance of collaboration between diagnostic developers and local communities to ensure the successful adoption and sustainability of these technologies.