The article reviews the evidence of human exposure to microplastics through seafood and discusses potential health effects. Microplastics, which are plastic particles smaller than 5 mm, are widely present in the marine environment due to human activities, and they are ingested by various marine species, including shellfish. The toxicity of microplastics is influenced by factors such as dose, polymer type, size, surface chemistry, and hydrophobicity. While the exact health impacts on humans are not fully understood, there is growing concern about the potential risks, especially considering the high consumption of seafood. The article highlights the need for further research to assess the impacts of microplastics on human health and recommends strategies for mitigation and adaptation to reduce microplastic pollution. Key areas of concern include the presence of chemicals in microplastics, the potential for chronic exposure, and the need for standardized methods for sampling and assessing microplastic exposure. The article also discusses the role of governments, industries, and civil society in addressing microplastic pollution and suggests that addressing these issues is crucial for protecting both marine ecosystems and human health.The article reviews the evidence of human exposure to microplastics through seafood and discusses potential health effects. Microplastics, which are plastic particles smaller than 5 mm, are widely present in the marine environment due to human activities, and they are ingested by various marine species, including shellfish. The toxicity of microplastics is influenced by factors such as dose, polymer type, size, surface chemistry, and hydrophobicity. While the exact health impacts on humans are not fully understood, there is growing concern about the potential risks, especially considering the high consumption of seafood. The article highlights the need for further research to assess the impacts of microplastics on human health and recommends strategies for mitigation and adaptation to reduce microplastic pollution. Key areas of concern include the presence of chemicals in microplastics, the potential for chronic exposure, and the need for standardized methods for sampling and assessing microplastic exposure. The article also discusses the role of governments, industries, and civil society in addressing microplastic pollution and suggests that addressing these issues is crucial for protecting both marine ecosystems and human health.