This study investigates cognitive dysfunction and brain changes in individuals with mild COVID-19 infection. A cross-sectional analysis of 97 unvaccinated, non-hospitalized individuals (median age 41 years) who had mild COVID-19 infection was conducted, with a median follow-up of 79 days after diagnosis. The participants underwent semi-structured interviews, neurological examinations, 3T-MRI scans, and neuropsychological assessments. The MRI study included white matter (WM) investigation with diffusion tensor imaging (DTI) and functional connectivity with resting-state functional MRI (RS-fMRI). The results showed that 36% of participants reported memory loss, 31% experienced fatigue, and 29% had headaches. Quantitative analyses confirmed symptoms of fatigue in 83% of participants, excessive somnolence in 35%, impaired phonemic verbal fluency in 21%, impaired verbal categorical fluency in 13%, and impaired logical memory immediate recall in 16%. DTI analyses revealed higher axial diffusivity values in post-infected patients compared to controls. However, there were no significant differences in functional connectivity of the posterior cingulum cortex between the two groups. No significant correlations were found between neuropsychological scores and neuroimaging features. The study suggests persistent cognitive impairment and subtle white matter abnormalities in individuals with mild COVID-19 infection without anxiety or depression symptoms. Longitudinal analyses are needed to determine whether these alterations are temporary or permanent.This study investigates cognitive dysfunction and brain changes in individuals with mild COVID-19 infection. A cross-sectional analysis of 97 unvaccinated, non-hospitalized individuals (median age 41 years) who had mild COVID-19 infection was conducted, with a median follow-up of 79 days after diagnosis. The participants underwent semi-structured interviews, neurological examinations, 3T-MRI scans, and neuropsychological assessments. The MRI study included white matter (WM) investigation with diffusion tensor imaging (DTI) and functional connectivity with resting-state functional MRI (RS-fMRI). The results showed that 36% of participants reported memory loss, 31% experienced fatigue, and 29% had headaches. Quantitative analyses confirmed symptoms of fatigue in 83% of participants, excessive somnolence in 35%, impaired phonemic verbal fluency in 21%, impaired verbal categorical fluency in 13%, and impaired logical memory immediate recall in 16%. DTI analyses revealed higher axial diffusivity values in post-infected patients compared to controls. However, there were no significant differences in functional connectivity of the posterior cingulum cortex between the two groups. No significant correlations were found between neuropsychological scores and neuroimaging features. The study suggests persistent cognitive impairment and subtle white matter abnormalities in individuals with mild COVID-19 infection without anxiety or depression symptoms. Longitudinal analyses are needed to determine whether these alterations are temporary or permanent.