A study investigated cognitive dysfunction and brain changes in 97 individuals with mild COVID-19 infection, without current or history of psychiatric symptoms. Participants underwent neuropsychological assessments, MRI scans, and interviews. Results showed that 83% of participants reported fatigue, 35% excessive somnolence, and 21% impaired verbal fluency. MRI analyses revealed higher axial diffusivity in post-infected patients compared to controls, but no significant differences in functional connectivity of the posterior cingulum cortex. No significant correlations were found between neuropsychological scores and neuroimaging features. The study suggests persistent cognitive impairment and subtle white matter abnormalities in individuals with mild infections. Longitudinal analyses are needed to determine if these changes are temporary or permanent. The study highlights the need for follow-up of patients with mild infections, as they may experience long-term cognitive and neurological effects. The findings indicate that SARS-CoV-2 can affect the brain even in individuals who did not require hospitalization. The study also notes that the definition of post-COVID-19 condition varies, which may affect the interpretation of results. The study's results suggest that mild infections can lead to persistent cognitive and neurological issues, even in the absence of anxiety or depression symptoms. The study emphasizes the importance of further research to understand the long-term effects of SARS-CoV-2 on the brain.A study investigated cognitive dysfunction and brain changes in 97 individuals with mild COVID-19 infection, without current or history of psychiatric symptoms. Participants underwent neuropsychological assessments, MRI scans, and interviews. Results showed that 83% of participants reported fatigue, 35% excessive somnolence, and 21% impaired verbal fluency. MRI analyses revealed higher axial diffusivity in post-infected patients compared to controls, but no significant differences in functional connectivity of the posterior cingulum cortex. No significant correlations were found between neuropsychological scores and neuroimaging features. The study suggests persistent cognitive impairment and subtle white matter abnormalities in individuals with mild infections. Longitudinal analyses are needed to determine if these changes are temporary or permanent. The study highlights the need for follow-up of patients with mild infections, as they may experience long-term cognitive and neurological effects. The findings indicate that SARS-CoV-2 can affect the brain even in individuals who did not require hospitalization. The study also notes that the definition of post-COVID-19 condition varies, which may affect the interpretation of results. The study's results suggest that mild infections can lead to persistent cognitive and neurological issues, even in the absence of anxiety or depression symptoms. The study emphasizes the importance of further research to understand the long-term effects of SARS-CoV-2 on the brain.