The article reviews the recent advances in understanding the mechanism of microtubule nucleation by γ-tubulin complexes. It highlights the role of γ-tubulin ring complex (γTuRC) and its components in microtubule initiation, emphasizing the importance of spatial and temporal control over this process. Recent structural studies have provided insights into the organization and function of γTuRC, confirming its role as a microtubule template. The crystal structure of γ-tubulin and the structure of the γ-tubulin small complex (γTuSC) have been determined, revealing the arrangement of γ-tubulins and their interactions with other proteins. The article also discusses the role of GCP4, GCP5, and GCP6 in γTuRC assembly and function, and the regulation of γTuRC activity through conformational changes in GCP3. Additionally, it explores the localization of γTuRC and its activation at specific cellular sites, suggesting a direct link between attachment and activation. The review concludes with a revised model of γTuRC assembly and the potential roles of nucleotide binding and hydrolysis in microtubule nucleation.The article reviews the recent advances in understanding the mechanism of microtubule nucleation by γ-tubulin complexes. It highlights the role of γ-tubulin ring complex (γTuRC) and its components in microtubule initiation, emphasizing the importance of spatial and temporal control over this process. Recent structural studies have provided insights into the organization and function of γTuRC, confirming its role as a microtubule template. The crystal structure of γ-tubulin and the structure of the γ-tubulin small complex (γTuSC) have been determined, revealing the arrangement of γ-tubulins and their interactions with other proteins. The article also discusses the role of GCP4, GCP5, and GCP6 in γTuRC assembly and function, and the regulation of γTuRC activity through conformational changes in GCP3. Additionally, it explores the localization of γTuRC and its activation at specific cellular sites, suggesting a direct link between attachment and activation. The review concludes with a revised model of γTuRC assembly and the potential roles of nucleotide binding and hydrolysis in microtubule nucleation.