This article discusses the development of a versatile strategy for creating robust biomedical coatings by mimicking the foot protein of Mytilus edulis. The study focuses on the synthesis of a catechol-rich polymer (CPA) through EDC/NHS chemistry, which can be used to create coatings with various functionalities. The research includes methods for characterizing the coatings, such as 1H-NMR, FTIR, water contact angle, XPS, and ellipsometry. The stability, chemical and mechanical robustness, and biological properties of the coatings were evaluated through various experiments, including tests on adhesion, mechanical strength, and antibacterial activity. The study also includes methods for quantifying amino and carboxyl groups, as well as for assessing the catalytic release of NO and clotting time. The article provides detailed protocols for preparing and testing the coatings, as well as for cell culture and in vivo stent implantation experiments. The results demonstrate the potential of the CPA coatings for biomedical applications due to their robustness, versatility, and biocompatibility.This article discusses the development of a versatile strategy for creating robust biomedical coatings by mimicking the foot protein of Mytilus edulis. The study focuses on the synthesis of a catechol-rich polymer (CPA) through EDC/NHS chemistry, which can be used to create coatings with various functionalities. The research includes methods for characterizing the coatings, such as 1H-NMR, FTIR, water contact angle, XPS, and ellipsometry. The stability, chemical and mechanical robustness, and biological properties of the coatings were evaluated through various experiments, including tests on adhesion, mechanical strength, and antibacterial activity. The study also includes methods for quantifying amino and carboxyl groups, as well as for assessing the catalytic release of NO and clotting time. The article provides detailed protocols for preparing and testing the coatings, as well as for cell culture and in vivo stent implantation experiments. The results demonstrate the potential of the CPA coatings for biomedical applications due to their robustness, versatility, and biocompatibility.