The article explores the intricate relationship between psychiatric disorders and the gut microbiota, highlighting the role of the gut-brain axis in modulating these conditions. It discusses how alterations in gut microbiota can influence brain processes, leading to disturbances in cognitive functions, emotional regulation, and behavioral patterns. The review emphasizes the potential of probiotic and prebiotic supplements in alleviating symptoms of major depressive disorder (MDD), anxiety, and schizophrenia by improving gut health. Additionally, it examines the antimicrobial effects of psychotropic drugs, such as antidepressants and antipsychotics, on the gut microbiome, suggesting their potential utility in combating bacterial infections. The article concludes by underscoring the importance of further research to fully understand and develop effective treatments for psychiatric disorders through the modulation of gut microbiota and the antimicrobial properties of psychotropic medications.The article explores the intricate relationship between psychiatric disorders and the gut microbiota, highlighting the role of the gut-brain axis in modulating these conditions. It discusses how alterations in gut microbiota can influence brain processes, leading to disturbances in cognitive functions, emotional regulation, and behavioral patterns. The review emphasizes the potential of probiotic and prebiotic supplements in alleviating symptoms of major depressive disorder (MDD), anxiety, and schizophrenia by improving gut health. Additionally, it examines the antimicrobial effects of psychotropic drugs, such as antidepressants and antipsychotics, on the gut microbiome, suggesting their potential utility in combating bacterial infections. The article concludes by underscoring the importance of further research to fully understand and develop effective treatments for psychiatric disorders through the modulation of gut microbiota and the antimicrobial properties of psychotropic medications.