The article "Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences" by Charlotte E. Sofield, Ryan S. Anderton, and Anastazja M. Gorecki provides a comprehensive review of the effects of microplastics on the gut-brain-axis. Microplastics, which are ubiquitous in the environment and consumed through drinking water and food, have been shown to cause gut microbiome dysbiosis, gastrointestinal inflammation, and immune activation. These effects can lead to systemic inflammation and the translocation of microplastics throughout the body, including the brain. The gut-brain-axis (GBA) is a bidirectional communication pathway between the gut and the nervous system, and disruptions in this axis can contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's. The review highlights the mechanisms by which microplastics damage the gut, including their interaction with the gut microbiome, increased gut permeability, and activation of the enteric immune system. Microplastics can also cross the blood-brain-barrier (BBB), leading to neuroinflammation, neurotoxicity, and neurodegeneration. The article discusses the current methods and limitations in studying the health effects of microplastics and emphasizes the need for more realistic exposure models. Overall, the findings suggest that microplastics are a significant environmental pollutant that can have widespread adverse effects on human health, particularly in the context of neurodegenerative diseases.The article "Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences" by Charlotte E. Sofield, Ryan S. Anderton, and Anastazja M. Gorecki provides a comprehensive review of the effects of microplastics on the gut-brain-axis. Microplastics, which are ubiquitous in the environment and consumed through drinking water and food, have been shown to cause gut microbiome dysbiosis, gastrointestinal inflammation, and immune activation. These effects can lead to systemic inflammation and the translocation of microplastics throughout the body, including the brain. The gut-brain-axis (GBA) is a bidirectional communication pathway between the gut and the nervous system, and disruptions in this axis can contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's. The review highlights the mechanisms by which microplastics damage the gut, including their interaction with the gut microbiome, increased gut permeability, and activation of the enteric immune system. Microplastics can also cross the blood-brain-barrier (BBB), leading to neuroinflammation, neurotoxicity, and neurodegeneration. The article discusses the current methods and limitations in studying the health effects of microplastics and emphasizes the need for more realistic exposure models. Overall, the findings suggest that microplastics are a significant environmental pollutant that can have widespread adverse effects on human health, particularly in the context of neurodegenerative diseases.