The article "Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches" by Tihamer Molnar et al. explores the role of mitochondrial dysfunction in the persistent symptoms of long COVID. The authors highlight that chronic fatigue, cognitive disturbances, and exercise intolerance are common symptoms, suggesting systemic alterations beyond the initial viral pathology. They discuss the potential mechanisms by which SARS-CoV-2 infection can lead to mitochondrial dysfunction, including direct interaction with mitochondria, structural damage, and dysregulation of mitochondrial bioenergetics. The review also examines biomarkers of mitochondrial dysfunction, such as peroxiredoxin-3 (PRDX3), and its association with specific symptoms like dizziness. Additionally, the article outlines potential therapeutic strategies, including pharmacological interventions, lifestyle modifications, exercise, and dietary approaches, emphasizing the need for further research and collaborative efforts to advance understanding and management of long COVID. The authors conclude by underscoring the critical role of mitochondrial dysfunction in long COVID and the potential for targeted therapies to improve patient outcomes.The article "Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches" by Tihamer Molnar et al. explores the role of mitochondrial dysfunction in the persistent symptoms of long COVID. The authors highlight that chronic fatigue, cognitive disturbances, and exercise intolerance are common symptoms, suggesting systemic alterations beyond the initial viral pathology. They discuss the potential mechanisms by which SARS-CoV-2 infection can lead to mitochondrial dysfunction, including direct interaction with mitochondria, structural damage, and dysregulation of mitochondrial bioenergetics. The review also examines biomarkers of mitochondrial dysfunction, such as peroxiredoxin-3 (PRDX3), and its association with specific symptoms like dizziness. Additionally, the article outlines potential therapeutic strategies, including pharmacological interventions, lifestyle modifications, exercise, and dietary approaches, emphasizing the need for further research and collaborative efforts to advance understanding and management of long COVID. The authors conclude by underscoring the critical role of mitochondrial dysfunction in long COVID and the potential for targeted therapies to improve patient outcomes.