The study investigates the potential of mobilizing bone marrow cells (BMC) to repair infarcted hearts. BMC, which have the capacity to differentiate into various cell types, were previously shown to differentiate into myocytes and vascular structures when injected into the border zone of acute infarcts. The current study hypothesized that BMC mobilized by stem cell factor (SCF) and granulocyte-colony-stimulating factor (G-CSF) would home to the infarcted region, replicate, differentiate, and promote myocardial repair. The results demonstrated that cytokine-mediated mobilization of BMC led to significant tissue regeneration 27 days after an acute myocardial infarct. This repair decreased mortality by 68%, reduced infarct size by 40%, cavitary dilation by 26%, and diastolic stress by 70%. Ejection fraction increased, and hemodynamics improved due to the formation of 15 × 10^6 new myocytes and connected arterioles and capillaries. The study concludes that mobilizing primitive BMC by cytokines offers a noninvasive therapeutic strategy for myocardial regeneration in ischemic heart disease and other cardiac pathologies.The study investigates the potential of mobilizing bone marrow cells (BMC) to repair infarcted hearts. BMC, which have the capacity to differentiate into various cell types, were previously shown to differentiate into myocytes and vascular structures when injected into the border zone of acute infarcts. The current study hypothesized that BMC mobilized by stem cell factor (SCF) and granulocyte-colony-stimulating factor (G-CSF) would home to the infarcted region, replicate, differentiate, and promote myocardial repair. The results demonstrated that cytokine-mediated mobilization of BMC led to significant tissue regeneration 27 days after an acute myocardial infarct. This repair decreased mortality by 68%, reduced infarct size by 40%, cavitary dilation by 26%, and diastolic stress by 70%. Ejection fraction increased, and hemodynamics improved due to the formation of 15 × 10^6 new myocytes and connected arterioles and capillaries. The study concludes that mobilizing primitive BMC by cytokines offers a noninvasive therapeutic strategy for myocardial regeneration in ischemic heart disease and other cardiac pathologies.