This study analyzes the factors affecting bank profitability in the eurozone from 2015 to 2020, using a random effects model, fixed effects model, and general method of moments (GMM). The research examines both bank-specific determinants (NPL, CIR, NIM, NIF, NIT) and macroeconomic determinants (GDP, INF, UNM, DEBT). The results show that NPL and CIR negatively impact bank profitability, while NIM, NIF, and NIT have a positive effect. GDP positively affects profitability, whereas INF, UNM, and DEBT have a negative impact. The study also highlights the importance of two less commonly used macroeconomic variables: unemployment rate and debt-to-GDP ratio. The findings indicate that bank-specific and macroeconomic factors significantly influence profitability, with variations across countries. The study contributes to the literature by employing different panel techniques and incorporating these two macroeconomic variables. The results suggest that improving macroeconomic conditions and managing bank-specific risks can enhance profitability in the eurozone. The study also identifies that the impact of these factors varies by country, providing insights for policymakers and bank managers. The research concludes that profitability is crucial for financial stability, regulatory compliance, and investor confidence. The study's main contributions include filling a gap in the literature on bank profitability determinants in the eurozone and introducing two less commonly used macroeconomic variables. The study's limitations include not accounting for economic cycles, and future research should analyze the impact of the pandemic on bank profitability.This study analyzes the factors affecting bank profitability in the eurozone from 2015 to 2020, using a random effects model, fixed effects model, and general method of moments (GMM). The research examines both bank-specific determinants (NPL, CIR, NIM, NIF, NIT) and macroeconomic determinants (GDP, INF, UNM, DEBT). The results show that NPL and CIR negatively impact bank profitability, while NIM, NIF, and NIT have a positive effect. GDP positively affects profitability, whereas INF, UNM, and DEBT have a negative impact. The study also highlights the importance of two less commonly used macroeconomic variables: unemployment rate and debt-to-GDP ratio. The findings indicate that bank-specific and macroeconomic factors significantly influence profitability, with variations across countries. The study contributes to the literature by employing different panel techniques and incorporating these two macroeconomic variables. The results suggest that improving macroeconomic conditions and managing bank-specific risks can enhance profitability in the eurozone. The study also identifies that the impact of these factors varies by country, providing insights for policymakers and bank managers. The research concludes that profitability is crucial for financial stability, regulatory compliance, and investor confidence. The study's main contributions include filling a gap in the literature on bank profitability determinants in the eurozone and introducing two less commonly used macroeconomic variables. The study's limitations include not accounting for economic cycles, and future research should analyze the impact of the pandemic on bank profitability.