This study investigates the cellular and molecular defects in schizophrenia (SCZD) using human induced pluripotent stem cells (hiPSCs) derived from SCZD patients. The researchers reprogrammed fibroblasts from four SCZD patients into hiPSCs and differentiated them into neurons. The SCZD hiPSC neurons showed reduced neuronal connectivity, decreased neurite number, and altered expression of synaptic proteins such as PSD95. Gene expression analysis revealed altered expression of components in the cAMP and WNT signaling pathways. Treatment with the antipsychotic Loxapine improved neuronal connectivity and altered gene expression in these neurons. The study provides insights into the cellular and molecular mechanisms underlying SCZD and demonstrates the potential of hiPSC technology in modeling complex genetic psychiatric disorders.This study investigates the cellular and molecular defects in schizophrenia (SCZD) using human induced pluripotent stem cells (hiPSCs) derived from SCZD patients. The researchers reprogrammed fibroblasts from four SCZD patients into hiPSCs and differentiated them into neurons. The SCZD hiPSC neurons showed reduced neuronal connectivity, decreased neurite number, and altered expression of synaptic proteins such as PSD95. Gene expression analysis revealed altered expression of components in the cAMP and WNT signaling pathways. Treatment with the antipsychotic Loxapine improved neuronal connectivity and altered gene expression in these neurons. The study provides insights into the cellular and molecular mechanisms underlying SCZD and demonstrates the potential of hiPSC technology in modeling complex genetic psychiatric disorders.