The article "Modulating root system architecture: cross-talk between auxin and phytohormones" by Mehmood Jan et al. explores the complex interactions between phytohormones, particularly auxin and cytokinin (CK), in regulating root development and architecture. The authors highlight the significant role of auxin in modulating various aspects of root growth, including primary root (PR) elongation, lateral root (LR) formation, adventitious root (AR) development, and root hair (RH) formation. They discuss how auxin signaling pathways, such as the PIN-formed (PIN) auxin transporters, are crucial for these processes. Additionally, the article reviews the cross-talk between auxin and other phytohormones, such as CK and strigolactones (SLs), and their effects on root architecture. CK is shown to regulate PR growth by inhibiting cell division and affecting auxin distribution, while SLs influence PR and AR growth but negatively impact LR growth. The authors also emphasize the importance of understanding these hormonal interactions for improving crop yield and stress resistance under various environmental conditions. The review concludes with a call for more systematic investigations and computational models to enhance our understanding of hormonal regulation in root development.The article "Modulating root system architecture: cross-talk between auxin and phytohormones" by Mehmood Jan et al. explores the complex interactions between phytohormones, particularly auxin and cytokinin (CK), in regulating root development and architecture. The authors highlight the significant role of auxin in modulating various aspects of root growth, including primary root (PR) elongation, lateral root (LR) formation, adventitious root (AR) development, and root hair (RH) formation. They discuss how auxin signaling pathways, such as the PIN-formed (PIN) auxin transporters, are crucial for these processes. Additionally, the article reviews the cross-talk between auxin and other phytohormones, such as CK and strigolactones (SLs), and their effects on root architecture. CK is shown to regulate PR growth by inhibiting cell division and affecting auxin distribution, while SLs influence PR and AR growth but negatively impact LR growth. The authors also emphasize the importance of understanding these hormonal interactions for improving crop yield and stress resistance under various environmental conditions. The review concludes with a call for more systematic investigations and computational models to enhance our understanding of hormonal regulation in root development.