This study investigates the molecular epidemiology of human *Streptococcus suis* infections in Europe, a zoonotic pathogen that can cause severe diseases such as meningitis and sepsis in humans. Despite being a notifiable disease in some countries, human *S. suis* infections are underreported in most European countries. The researchers surveyed 7 reference laboratories and conducted a systematic review of scientific literature to identify 236 cases of human *S. suis* infection. Whole-genome sequencing was performed on 46 zoonotic isolates, and a core-genome phylogeny was constructed. Clonal complex (CC) 1 isolates accounted for 87% of typed human infections, with CC20, CC25, CC87, and CC94 also causing infections. The study highlights the emergence of diverse zoonotic clades and the severity of illness in humans, suggesting that *S. suis* infection should be classified as a notifiable condition. The findings also indicate that the incidence of human *S. suis* infections in Europe is likely underestimated due to the lack of centralized surveillance systems and the non-notifiable status of the disease. The study recommends making *S. suis* infections notifiable in Europe to improve surveillance and detect potential human-to-human transmission.This study investigates the molecular epidemiology of human *Streptococcus suis* infections in Europe, a zoonotic pathogen that can cause severe diseases such as meningitis and sepsis in humans. Despite being a notifiable disease in some countries, human *S. suis* infections are underreported in most European countries. The researchers surveyed 7 reference laboratories and conducted a systematic review of scientific literature to identify 236 cases of human *S. suis* infection. Whole-genome sequencing was performed on 46 zoonotic isolates, and a core-genome phylogeny was constructed. Clonal complex (CC) 1 isolates accounted for 87% of typed human infections, with CC20, CC25, CC87, and CC94 also causing infections. The study highlights the emergence of diverse zoonotic clades and the severity of illness in humans, suggesting that *S. suis* infection should be classified as a notifiable condition. The findings also indicate that the incidence of human *S. suis* infections in Europe is likely underestimated due to the lack of centralized surveillance systems and the non-notifiable status of the disease. The study recommends making *S. suis* infections notifiable in Europe to improve surveillance and detect potential human-to-human transmission.