This review discusses the role of molecular inflammation in aging and age-related diseases. It highlights how low-grade, unresolved inflammation is a key mechanism linking normal aging to pathological processes. The review covers the accumulation of pro-inflammatory mediators (e.g., TNF-α, IL-1β, COX-2, iNOS) due to age-related redox imbalances, which activate various inflammatory signaling pathways, including the NF-κB pathway. The anti-inflammatory effects of calorie restriction (CR) and physical exercise are also discussed, emphasizing their ability to maintain redox balance and suppress pro-inflammatory responses. The review further explores the oxidative stress-induced redox imbalance as a major factor in systemic inflammation and its role in age-related diseases such as obesity, sarcopenia, dementia, atherosclerosis, cancer, and osteoporosis. Finally, it suggests that interventions targeting chronic inflammation may promote healthy longevity by reducing age-related diseases.This review discusses the role of molecular inflammation in aging and age-related diseases. It highlights how low-grade, unresolved inflammation is a key mechanism linking normal aging to pathological processes. The review covers the accumulation of pro-inflammatory mediators (e.g., TNF-α, IL-1β, COX-2, iNOS) due to age-related redox imbalances, which activate various inflammatory signaling pathways, including the NF-κB pathway. The anti-inflammatory effects of calorie restriction (CR) and physical exercise are also discussed, emphasizing their ability to maintain redox balance and suppress pro-inflammatory responses. The review further explores the oxidative stress-induced redox imbalance as a major factor in systemic inflammation and its role in age-related diseases such as obesity, sarcopenia, dementia, atherosclerosis, cancer, and osteoporosis. Finally, it suggests that interventions targeting chronic inflammation may promote healthy longevity by reducing age-related diseases.