Molecularly Imprinted Polymers (MIPs) are polymeric materials designed to mimic natural recognition systems, such as antibodies, through molecular imprinting technology (MIT). This review discusses the preparation, properties, and applications of MIPs in various fields, including chemical sensing, separation science, drug delivery, and catalysis. The process involves the formation of a complex between a template molecule and a functional monomer, followed by polymerization and template removal, leaving behind specific recognition sites. MIPs offer high selectivity and affinity for target molecules, are robust, and can be synthesized cost-effectively. They are used in chromatography, solid-phase extraction, sensors, and biosensors. The review highlights the importance of interaction between template and polymer functionalities, and discusses synthesis methods to improve recognition properties. MIPs have been applied in various areas, including separation techniques, drug delivery, and environmental analysis. Recent studies focus on optimizing MIP synthesis parameters, such as cross-linkers, solvents, and functional monomers, to enhance performance. MIPs are also being explored for water-compatible applications and in medical therapies. The review emphasizes the potential of MIPs in future applications, including improved chromatographic efficiency, selective extraction, and drug delivery systems.Molecularly Imprinted Polymers (MIPs) are polymeric materials designed to mimic natural recognition systems, such as antibodies, through molecular imprinting technology (MIT). This review discusses the preparation, properties, and applications of MIPs in various fields, including chemical sensing, separation science, drug delivery, and catalysis. The process involves the formation of a complex between a template molecule and a functional monomer, followed by polymerization and template removal, leaving behind specific recognition sites. MIPs offer high selectivity and affinity for target molecules, are robust, and can be synthesized cost-effectively. They are used in chromatography, solid-phase extraction, sensors, and biosensors. The review highlights the importance of interaction between template and polymer functionalities, and discusses synthesis methods to improve recognition properties. MIPs have been applied in various areas, including separation techniques, drug delivery, and environmental analysis. Recent studies focus on optimizing MIP synthesis parameters, such as cross-linkers, solvents, and functional monomers, to enhance performance. MIPs are also being explored for water-compatible applications and in medical therapies. The review emphasizes the potential of MIPs in future applications, including improved chromatographic efficiency, selective extraction, and drug delivery systems.