This systematic review and meta-analysis aimed to identify and estimate the prevalence of long-term effects of COVID-19. The study searched LitCOVID and Embase for articles published before January 1, 2021, with a minimum of 100 patients. A total of 15 studies met the inclusion criteria, involving 47,910 patients aged 17-87 years. The prevalence of 55 long-term effects was estimated, with 21 meta-analyses performed. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). The study highlights the need for multidisciplinary teams to develop preventive measures, rehabilitation techniques, and clinical management strategies for long COVID-19 care.This systematic review and meta-analysis aimed to identify and estimate the prevalence of long-term effects of COVID-19. The study searched LitCOVID and Embase for articles published before January 1, 2021, with a minimum of 100 patients. A total of 15 studies met the inclusion criteria, involving 47,910 patients aged 17-87 years. The prevalence of 55 long-term effects was estimated, with 21 meta-analyses performed. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). The study highlights the need for multidisciplinary teams to develop preventive measures, rehabilitation techniques, and clinical management strategies for long COVID-19 care.