The book "Multisystem Inflammatory Syndrome - Natural History" edited by Nicolás Padilla-Raygoza provides a comprehensive overview of the natural history of Multisystem Inflammatory Syndrome (MIS), which emerged as a complication of COVID-19. The book is divided into three sections: an introduction, a discussion of the prepathogenic period, and an examination of the clinical stage. The prepathogenic period focuses on the ecological triad—agent, host, and environment—and the clinical stage reviews the clinical manifestations, complications, sequelae, and causes of death of MIS. The book highlights the importance of understanding the natural history of MIS to develop effective prevention and treatment strategies. It also addresses the differences between MIS in children and adults, noting that children generally recover faster from generalized inflammation and may not have severe cardiac complications. The book emphasizes the role of chronic low-grade inflammation, such as obesity, in exacerbating the systemic inflammatory response. Overall, the book aims to provide a detailed understanding of MIS, including its pathogenesis, risk factors, and diverse outcomes, to aid in the management and prevention of this condition.The book "Multisystem Inflammatory Syndrome - Natural History" edited by Nicolás Padilla-Raygoza provides a comprehensive overview of the natural history of Multisystem Inflammatory Syndrome (MIS), which emerged as a complication of COVID-19. The book is divided into three sections: an introduction, a discussion of the prepathogenic period, and an examination of the clinical stage. The prepathogenic period focuses on the ecological triad—agent, host, and environment—and the clinical stage reviews the clinical manifestations, complications, sequelae, and causes of death of MIS. The book highlights the importance of understanding the natural history of MIS to develop effective prevention and treatment strategies. It also addresses the differences between MIS in children and adults, noting that children generally recover faster from generalized inflammation and may not have severe cardiac complications. The book emphasizes the role of chronic low-grade inflammation, such as obesity, in exacerbating the systemic inflammatory response. Overall, the book aims to provide a detailed understanding of MIS, including its pathogenesis, risk factors, and diverse outcomes, to aid in the management and prevention of this condition.