A systematic review of 10 randomized controlled trials found that intensive multidisciplinary biopsychosocial rehabilitation with functional restoration significantly improves function and reduces pain in patients with chronic low back pain compared to non-multidisciplinary treatments. Moderate evidence suggests it also reduces pain compared to outpatient non-multidisciplinary rehabilitation or usual care. However, there is contradictory evidence regarding vocational outcomes, with some trials showing improvements in work readiness and others no significant reduction in sick leave. Less intensive outpatient psychophysical treatments did not improve pain, function, or vocational outcomes compared to non-multidisciplinary outpatient therapy or usual care. Few trials reported effects on quality of life or global assessments. The review concluded that intensive multidisciplinary biopsychosocial rehabilitation with functional restoration reduces pain and improves function in patients with chronic low back pain, while less intensive interventions did not show improvements in clinically relevant outcomes. The study was conducted under the sponsorship of the Cochrane Collaboration and followed methodological guidelines. The review included 1964 patients with disabling low back pain for more than three months. The trials were performed in various countries, including Scandinavia, Germany, Australia, and Canada. The study found that most trials measured relevant outcomes and had acceptable dropout rates. However, the methodological quality varied, and some trials did not achieve blinding of patients or care providers. The review also highlighted the need for further research on the cost-effectiveness of intensive multidisciplinary rehabilitation. The study concluded that intensive multidisciplinary rehabilitation with a functional restoration approach produces improvements in pain and function in patients with chronic disabling low back pain, while less intensive treatments did not seem to be effective. The results may not apply to most patients seen in primary care or to less established programs. The study emphasized the importance of considering the content of multidisciplinary rehabilitation programs when referring patients for treatment. The review also noted that the findings should be interpreted in the context of potential biases in systematic reviews and the limitations of the study. The study aimed to assess the effect of multidisciplinary biopsychosocial rehabilitation on clinically relevant outcomes in patients with chronic low back pain. The review included 10 randomized controlled trials and found that intensive multidisciplinary rehabilitation with functional restoration improved function and reduced pain compared to non-multidisciplinary treatments. The study also highlighted the need for further research on the cost-effectiveness of intensive multidisciplinary rehabilitation. The review concluded that intensive multidisciplinary biopsychosocial rehabilitation with functional restoration produces greater improvements in pain and function for patients with disabling chronic low back pain than less intensive multidisciplinary or non-multidisciplinary rehabilitation or usual care. Whether the improvements are worth the expense of these intensive programs is open for discussion. The final judgment will depend on societal resources, available alternatives, and the value attached to the observed decreases in human suffering from back pain. The study was conducted by a team of researchers from various institutions and was funded by different organizations. The authorsA systematic review of 10 randomized controlled trials found that intensive multidisciplinary biopsychosocial rehabilitation with functional restoration significantly improves function and reduces pain in patients with chronic low back pain compared to non-multidisciplinary treatments. Moderate evidence suggests it also reduces pain compared to outpatient non-multidisciplinary rehabilitation or usual care. However, there is contradictory evidence regarding vocational outcomes, with some trials showing improvements in work readiness and others no significant reduction in sick leave. Less intensive outpatient psychophysical treatments did not improve pain, function, or vocational outcomes compared to non-multidisciplinary outpatient therapy or usual care. Few trials reported effects on quality of life or global assessments. The review concluded that intensive multidisciplinary biopsychosocial rehabilitation with functional restoration reduces pain and improves function in patients with chronic low back pain, while less intensive interventions did not show improvements in clinically relevant outcomes. The study was conducted under the sponsorship of the Cochrane Collaboration and followed methodological guidelines. The review included 1964 patients with disabling low back pain for more than three months. The trials were performed in various countries, including Scandinavia, Germany, Australia, and Canada. The study found that most trials measured relevant outcomes and had acceptable dropout rates. However, the methodological quality varied, and some trials did not achieve blinding of patients or care providers. The review also highlighted the need for further research on the cost-effectiveness of intensive multidisciplinary rehabilitation. The study concluded that intensive multidisciplinary rehabilitation with a functional restoration approach produces improvements in pain and function in patients with chronic disabling low back pain, while less intensive treatments did not seem to be effective. The results may not apply to most patients seen in primary care or to less established programs. The study emphasized the importance of considering the content of multidisciplinary rehabilitation programs when referring patients for treatment. The review also noted that the findings should be interpreted in the context of potential biases in systematic reviews and the limitations of the study. The study aimed to assess the effect of multidisciplinary biopsychosocial rehabilitation on clinically relevant outcomes in patients with chronic low back pain. The review included 10 randomized controlled trials and found that intensive multidisciplinary rehabilitation with functional restoration improved function and reduced pain compared to non-multidisciplinary treatments. The study also highlighted the need for further research on the cost-effectiveness of intensive multidisciplinary rehabilitation. The review concluded that intensive multidisciplinary biopsychosocial rehabilitation with functional restoration produces greater improvements in pain and function for patients with disabling chronic low back pain than less intensive multidisciplinary or non-multidisciplinary rehabilitation or usual care. Whether the improvements are worth the expense of these intensive programs is open for discussion. The final judgment will depend on societal resources, available alternatives, and the value attached to the observed decreases in human suffering from back pain. The study was conducted by a team of researchers from various institutions and was funded by different organizations. The authors