The chapter discusses the multifunctional nanofibrous membranes as a promising solution for integrated air purification. Air pollutants, including particulate matter (PM), volatile organic compounds (VOCs), nitrogen oxides (NOx), sulfur dioxide (SO2), and pathogenic microorganisms, have significant adverse effects on both ecosystems and human health. Traditional air purification technologies often suffer from high energy consumption, maintenance costs, and complexity. The review highlights the potential of multifunctional nanofibrous membranes, which can effectively remove multiple air pollutants through synergistic integration with functional materials. These materials, such as those with catalytic, adsorption, and antimicrobial properties, are incorporated into the nanofibrous membranes to enhance their performance. The chapter explores design concepts, fabrication strategies, preparation methods, PM removal mechanisms, and performance metrics of these membranes. It also outlines methods for removing various air pollutants and reviews different air purification materials. Finally, it emphasizes the state-of-the-art design approaches and advancements in multifunctional nanofibrous membranes for integrated air purification.The chapter discusses the multifunctional nanofibrous membranes as a promising solution for integrated air purification. Air pollutants, including particulate matter (PM), volatile organic compounds (VOCs), nitrogen oxides (NOx), sulfur dioxide (SO2), and pathogenic microorganisms, have significant adverse effects on both ecosystems and human health. Traditional air purification technologies often suffer from high energy consumption, maintenance costs, and complexity. The review highlights the potential of multifunctional nanofibrous membranes, which can effectively remove multiple air pollutants through synergistic integration with functional materials. These materials, such as those with catalytic, adsorption, and antimicrobial properties, are incorporated into the nanofibrous membranes to enhance their performance. The chapter explores design concepts, fabrication strategies, preparation methods, PM removal mechanisms, and performance metrics of these membranes. It also outlines methods for removing various air pollutants and reviews different air purification materials. Finally, it emphasizes the state-of-the-art design approaches and advancements in multifunctional nanofibrous membranes for integrated air purification.