The paper presents a novel approach to multiplexed 3D super-resolution imaging using DNA-PAINT and Exchange-PAINT. DNA-PAINT, which stands for Point Accumulation for Imaging in Nanoscale Topography, uses transient binding of short fluorescently labeled oligonucleotides to achieve sub-10 nm spatial resolution in vitro. The authors demonstrate this method on synthetic DNA structures and achieve ten "color" super-resolution imaging. Exchange-PAINT is a novel multiplexing approach that allows sequential imaging of multiple targets using only a single dye and laser source. This method is demonstrated on synthetic DNA structures and fixed cells, achieving four "color" imaging of proteins. The authors discuss the advantages of these methods over traditional super-resolution techniques and their potential for studying complex biomolecular systems.The paper presents a novel approach to multiplexed 3D super-resolution imaging using DNA-PAINT and Exchange-PAINT. DNA-PAINT, which stands for Point Accumulation for Imaging in Nanoscale Topography, uses transient binding of short fluorescently labeled oligonucleotides to achieve sub-10 nm spatial resolution in vitro. The authors demonstrate this method on synthetic DNA structures and achieve ten "color" super-resolution imaging. Exchange-PAINT is a novel multiplexing approach that allows sequential imaging of multiple targets using only a single dye and laser source. This method is demonstrated on synthetic DNA structures and fixed cells, achieving four "color" imaging of proteins. The authors discuss the advantages of these methods over traditional super-resolution techniques and their potential for studying complex biomolecular systems.