The study investigates the role of multisensory gamma stimulation in promoting glymphatic clearance of amyloid in the brain. Multisensory 40 Hz stimulation, which increases neural activity in multiple brain regions, was found to enhance the influx of cerebrospinal fluid (CSF) and the efflux of interstitial fluid (ISF) in the cortex of 5XFAD mice, a model of Alzheimer's disease. This stimulation was associated with increased aquaporin-4 (AQP4) polarization along astrocytic endfeet and dilation of meningeal lymphatic vessels. Inhibiting glymphatic clearance, such as by using the small molecule TGN020, reduced the effectiveness of multisensory 40 Hz stimulation in clearing amyloid. The study also found that vasoactive intestinal peptide (VIP) interneurons play a crucial role in facilitating glymphatic clearance by regulating arterial pulsatility. These findings suggest that multisensory gamma stimulation can recruit the glymphatic system to remove brain amyloid, providing a novel mechanism for therapeutic intervention in Alzheimer's disease.The study investigates the role of multisensory gamma stimulation in promoting glymphatic clearance of amyloid in the brain. Multisensory 40 Hz stimulation, which increases neural activity in multiple brain regions, was found to enhance the influx of cerebrospinal fluid (CSF) and the efflux of interstitial fluid (ISF) in the cortex of 5XFAD mice, a model of Alzheimer's disease. This stimulation was associated with increased aquaporin-4 (AQP4) polarization along astrocytic endfeet and dilation of meningeal lymphatic vessels. Inhibiting glymphatic clearance, such as by using the small molecule TGN020, reduced the effectiveness of multisensory 40 Hz stimulation in clearing amyloid. The study also found that vasoactive intestinal peptide (VIP) interneurons play a crucial role in facilitating glymphatic clearance by regulating arterial pulsatility. These findings suggest that multisensory gamma stimulation can recruit the glymphatic system to remove brain amyloid, providing a novel mechanism for therapeutic intervention in Alzheimer's disease.