The article describes a study on multisystem inflammatory syndrome in children (MIS-C) in New York State, which is linked to coronavirus disease 2019 (Covid-19). The New York State Department of Health established active surveillance to track hospitalized patients with MIS-C. Between March 1 and May 10, 2020, 191 potential cases were reported, with 95 confirmed and 4 suspected. The majority of patients were male, with a significant proportion being Black and Hispanic. Most patients presented with fever, tachycardia, gastrointestinal symptoms, and rash. Elevated levels of inflammatory markers were common, and many required vasopressor support and ICU admission. Cardiac dysfunction was a common complication, with 53% of patients having myocarditis. Two patients died, and the median length of hospital stay was 6 days. The study found that MIS-C occurred in association with widespread SARS-CoV-2 transmission, and it was a hyperinflammatory syndrome with dermatologic, mucocutaneous, and gastrointestinal manifestations. The study also noted that MIS-C was more common in younger children and that the syndrome was associated with cardiac dysfunction. The findings suggest that MIS-C is a postinfectious, inflammatory process related to Covid-19. The study highlights the importance of surveillance for MIS-C, particularly in areas with high SARS-CoV-2 transmission. The authors conclude that MIS-C is a significant concern and that further research is needed to understand its mechanisms and long-term outcomes.The article describes a study on multisystem inflammatory syndrome in children (MIS-C) in New York State, which is linked to coronavirus disease 2019 (Covid-19). The New York State Department of Health established active surveillance to track hospitalized patients with MIS-C. Between March 1 and May 10, 2020, 191 potential cases were reported, with 95 confirmed and 4 suspected. The majority of patients were male, with a significant proportion being Black and Hispanic. Most patients presented with fever, tachycardia, gastrointestinal symptoms, and rash. Elevated levels of inflammatory markers were common, and many required vasopressor support and ICU admission. Cardiac dysfunction was a common complication, with 53% of patients having myocarditis. Two patients died, and the median length of hospital stay was 6 days. The study found that MIS-C occurred in association with widespread SARS-CoV-2 transmission, and it was a hyperinflammatory syndrome with dermatologic, mucocutaneous, and gastrointestinal manifestations. The study also noted that MIS-C was more common in younger children and that the syndrome was associated with cardiac dysfunction. The findings suggest that MIS-C is a postinfectious, inflammatory process related to Covid-19. The study highlights the importance of surveillance for MIS-C, particularly in areas with high SARS-CoV-2 transmission. The authors conclude that MIS-C is a significant concern and that further research is needed to understand its mechanisms and long-term outcomes.