The chapter discusses the adhesive properties of mussels and their potential applications in synthetic adhesives. Mussels attach to solid surfaces in the sea, requiring rapid, strong, and tough adhesion to withstand wave action. The chapter highlights the challenges of adhesion in wet polar environments and the importance of understanding the adhesive chemistry of mussels. Key features of mussel adhesives include the presence of Dopa, a catecholic functionality, which enhances adhesion. Synthetic polymers functionalized with catechols have been developed to mimic these properties, particularly for biomedical applications such as adhesives, sealants, coatings, and anchoring materials. The chapter also delves into the structure and function of mussel byssal plaques, which are composed of multiple proteins, including mfp-2, mfp-3, mfp-4, mfp-5, and mfp-6, each with specific roles in adhesion. The chapter concludes by discussing the development of synthetic mussel mimetic polymers and their potential in medical applications, emphasizing the importance of Dopa in interfacial adhesion and the versatility of these materials in bonding with both inorganic and organic surfaces.The chapter discusses the adhesive properties of mussels and their potential applications in synthetic adhesives. Mussels attach to solid surfaces in the sea, requiring rapid, strong, and tough adhesion to withstand wave action. The chapter highlights the challenges of adhesion in wet polar environments and the importance of understanding the adhesive chemistry of mussels. Key features of mussel adhesives include the presence of Dopa, a catecholic functionality, which enhances adhesion. Synthetic polymers functionalized with catechols have been developed to mimic these properties, particularly for biomedical applications such as adhesives, sealants, coatings, and anchoring materials. The chapter also delves into the structure and function of mussel byssal plaques, which are composed of multiple proteins, including mfp-2, mfp-3, mfp-4, mfp-5, and mfp-6, each with specific roles in adhesion. The chapter concludes by discussing the development of synthetic mussel mimetic polymers and their potential in medical applications, emphasizing the importance of Dopa in interfacial adhesion and the versatility of these materials in bonding with both inorganic and organic surfaces.