This manuscript outlines the author's vision for the development of electric-field (EF)-mediated chemistry by 2050. The author discusses the application of oriented-external electric fields (OEEFs) on chemical reactions and their experimental verification. The perspective also explores other methods of generating EFs, such as pH-switchable charges, ionic additives, and water droplets. Key conceptual principles, including the "reaction-axis rule" and the ability of OEEFs to act as tweezers, are highlighted. The author emphasizes the potential of OEEFs in continuous-flow setups, which could scale up to molar concentrations. The vision concludes with the expectation that OEEF usage will significantly impact chemical education and the synthesis of new molecules by 2050. The manuscript provides a detailed overview of the theoretical predictions, experimental tests, and future applications of OEEFs in chemistry.This manuscript outlines the author's vision for the development of electric-field (EF)-mediated chemistry by 2050. The author discusses the application of oriented-external electric fields (OEEFs) on chemical reactions and their experimental verification. The perspective also explores other methods of generating EFs, such as pH-switchable charges, ionic additives, and water droplets. Key conceptual principles, including the "reaction-axis rule" and the ability of OEEFs to act as tweezers, are highlighted. The author emphasizes the potential of OEEFs in continuous-flow setups, which could scale up to molar concentrations. The vision concludes with the expectation that OEEF usage will significantly impact chemical education and the synthesis of new molecules by 2050. The manuscript provides a detailed overview of the theoretical predictions, experimental tests, and future applications of OEEFs in chemistry.