This review discusses the state-of-the-art in the use of molecularly imprinted polymers (MIPs) as solid-phase extraction materials for the analysis of mycotoxin contamination in food and beverages. Mycotoxins, toxic metabolites produced by molds, pose significant health risks due to their acute and chronic toxicity. Contemporary analytical methods are sensitive enough for contamination detection and quantification, but direct application on real samples is challenging due to matrix complexity and the need for clean-up and preconcentration steps. MIPs, artificial receptors that mimic natural antibodies, are increasingly used in extraction methods to address these issues. The review covers the development and application of MIPs, focusing on the use of mimic molecules in the synthesis of mycotoxin-imprinted materials, their application in real food samples, and the development of advanced extraction methods involving molecular imprinting technology. Key contributions include the discussion of the drawbacks and remedies in mycotoxin imprinting, such as the use of mimic templates and fragmental templates, and the solid-phase polymer synthesis approach. The review also highlights the use of MIPs in sample preparation for mycotoxin detection, including solid-phase extraction with commercial and homemade MIPs, on-line solid-phase extraction, dispersive solid-phase microextraction, magnetic solid-phase extraction, and stir bar sorptive extraction. Despite the challenges, the continuous evolution of molecular imprinting technology, particularly towards nanostructured materials, suggests that MIP-based extraction techniques will likely evolve further in terms of selectivity, multiple targets, and reduced matrix effects.This review discusses the state-of-the-art in the use of molecularly imprinted polymers (MIPs) as solid-phase extraction materials for the analysis of mycotoxin contamination in food and beverages. Mycotoxins, toxic metabolites produced by molds, pose significant health risks due to their acute and chronic toxicity. Contemporary analytical methods are sensitive enough for contamination detection and quantification, but direct application on real samples is challenging due to matrix complexity and the need for clean-up and preconcentration steps. MIPs, artificial receptors that mimic natural antibodies, are increasingly used in extraction methods to address these issues. The review covers the development and application of MIPs, focusing on the use of mimic molecules in the synthesis of mycotoxin-imprinted materials, their application in real food samples, and the development of advanced extraction methods involving molecular imprinting technology. Key contributions include the discussion of the drawbacks and remedies in mycotoxin imprinting, such as the use of mimic templates and fragmental templates, and the solid-phase polymer synthesis approach. The review also highlights the use of MIPs in sample preparation for mycotoxin detection, including solid-phase extraction with commercial and homemade MIPs, on-line solid-phase extraction, dispersive solid-phase microextraction, magnetic solid-phase extraction, and stir bar sorptive extraction. Despite the challenges, the continuous evolution of molecular imprinting technology, particularly towards nanostructured materials, suggests that MIP-based extraction techniques will likely evolve further in terms of selectivity, multiple targets, and reduced matrix effects.