The paper provides an updated overview of the predatory behavior of *Myxococcus xanthus*, a soil-dwelling bacterial predator known for its social and multicellular behavior. *M. xanthus* forms multicellular fruiting bodies to produce resistant myxospores when nutrients are scarce, but it can also initiate predation to feed on various Gram-positive and Gram-negative bacteria, as well as eukaryotic microorganisms. The predatory process involves multiple mechanisms, including motility systems for tracking prey, short-range production of secondary metabolites and hydrolytic enzymes for killing prey, and contact-dependent mechanisms such as Tad-like and type III secretion systems for cell-to-cell killing. Recent studies have also highlighted the role of metals, particularly copper and iron, in inducing oxidative stress and competing for essential metals during predation. The paper reviews these mechanisms, recent findings, and transcriptomic data, emphasizing the multifactorial nature of *M. xanthus* predation and its importance in shaping microbial communities in natural environments.The paper provides an updated overview of the predatory behavior of *Myxococcus xanthus*, a soil-dwelling bacterial predator known for its social and multicellular behavior. *M. xanthus* forms multicellular fruiting bodies to produce resistant myxospores when nutrients are scarce, but it can also initiate predation to feed on various Gram-positive and Gram-negative bacteria, as well as eukaryotic microorganisms. The predatory process involves multiple mechanisms, including motility systems for tracking prey, short-range production of secondary metabolites and hydrolytic enzymes for killing prey, and contact-dependent mechanisms such as Tad-like and type III secretion systems for cell-to-cell killing. Recent studies have also highlighted the role of metals, particularly copper and iron, in inducing oxidative stress and competing for essential metals during predation. The paper reviews these mechanisms, recent findings, and transcriptomic data, emphasizing the multifactorial nature of *M. xanthus* predation and its importance in shaping microbial communities in natural environments.