This review explores the antiviral potential of N-heterocyclic compounds, focusing on five- and six-membered rings with significant biological activities. N-heterocycles are crucial in drug development due to their diverse pharmacological properties, including antiviral, anticancer, and anti-inflammatory effects. The review highlights recent advancements in the synthesis and structure-activity relationship (SAR) analysis of N-heterocyclic compounds for antiviral applications. It discusses various N-heterocycles, such as pyrazoles, imidazoles, thiazoles, thiadiazoles, and triazoles, emphasizing their antiviral mechanisms and efficacy against different viruses, including HIV, hepatitis C, influenza, and others. The study identifies key compounds with promising antiviral activity, demonstrating their potential as new drug candidates. The review also addresses the challenges in antiviral therapy, such as drug resistance and side effects, and highlights the importance of developing novel compounds with diverse mechanisms of action. Overall, the review provides a comprehensive overview of N-heterocyclic compounds as promising antiviral agents, offering insights into their potential for future drug development.This review explores the antiviral potential of N-heterocyclic compounds, focusing on five- and six-membered rings with significant biological activities. N-heterocycles are crucial in drug development due to their diverse pharmacological properties, including antiviral, anticancer, and anti-inflammatory effects. The review highlights recent advancements in the synthesis and structure-activity relationship (SAR) analysis of N-heterocyclic compounds for antiviral applications. It discusses various N-heterocycles, such as pyrazoles, imidazoles, thiazoles, thiadiazoles, and triazoles, emphasizing their antiviral mechanisms and efficacy against different viruses, including HIV, hepatitis C, influenza, and others. The study identifies key compounds with promising antiviral activity, demonstrating their potential as new drug candidates. The review also addresses the challenges in antiviral therapy, such as drug resistance and side effects, and highlights the importance of developing novel compounds with diverse mechanisms of action. Overall, the review provides a comprehensive overview of N-heterocyclic compounds as promising antiviral agents, offering insights into their potential for future drug development.