This review focuses on the antiviral properties of recently synthesized five- and six-membered N-heterocyclic molecules, highlighting their potential as effective antiviral drugs. N-heterocycles can interfere with various stages of the viral life cycle, including viral entry into host cells, genome replication, and the production of new viral particles. They can also stimulate the host's immune system to produce antiviral cytokines and chemokines, which can inhibit viral replication. The review covers a wide range of N-heterocyclic compounds, including pyrazole, imidazole, thiazole, thiazolidinone, thiadiazole, triazole, oxazole, and oxadiazole derivatives, detailing their antiviral activities and structure-activity relationship (SAR) analyses. These compounds have shown promise in treating various viral infections, such as HIV, hepatitis C, influenza, and herpes simplex virus. The review aims to identify robust scaffolds that can be further developed into effective antiviral drugs with minimal side effects.This review focuses on the antiviral properties of recently synthesized five- and six-membered N-heterocyclic molecules, highlighting their potential as effective antiviral drugs. N-heterocycles can interfere with various stages of the viral life cycle, including viral entry into host cells, genome replication, and the production of new viral particles. They can also stimulate the host's immune system to produce antiviral cytokines and chemokines, which can inhibit viral replication. The review covers a wide range of N-heterocyclic compounds, including pyrazole, imidazole, thiazole, thiazolidinone, thiadiazole, triazole, oxazole, and oxadiazole derivatives, detailing their antiviral activities and structure-activity relationship (SAR) analyses. These compounds have shown promise in treating various viral infections, such as HIV, hepatitis C, influenza, and herpes simplex virus. The review aims to identify robust scaffolds that can be further developed into effective antiviral drugs with minimal side effects.