The article discusses the use of nanobiomaterials and bioinks in 3D bioprinting for tissue engineering and the creation of artificial human organs. Bioinks are combinations of live cells and biomaterials, often blended with tissue factors or other biomolecules, used to create 3D structures that mimic the properties of natural human tissues or organs. These structures are crucial for healing damaged tissues, repairing organs, and testing new medications and vaccinations. The challenge lies in ensuring that specific physicochemical and biological signals are harmoniously present to regulate cell activity and stimulate stem cell differentiation. Nano-biomaterials can control cell fate, enabling the biofabrication of useful structures. Nano-composite bio-inks can create scaffolds that instruct cell behavior and allow for high-quality imaging. Additionally, incorporating nanoparticles into 3D printed configurations can make these structures responsive to external physical stimuli, enhancing their potential in healthcare applications. The study highlights the development of biological systems with functionalities such as motion, shape change, and sensing, emphasizing the promise of nanobiomaterials in tissue regeneration strategies.The article discusses the use of nanobiomaterials and bioinks in 3D bioprinting for tissue engineering and the creation of artificial human organs. Bioinks are combinations of live cells and biomaterials, often blended with tissue factors or other biomolecules, used to create 3D structures that mimic the properties of natural human tissues or organs. These structures are crucial for healing damaged tissues, repairing organs, and testing new medications and vaccinations. The challenge lies in ensuring that specific physicochemical and biological signals are harmoniously present to regulate cell activity and stimulate stem cell differentiation. Nano-biomaterials can control cell fate, enabling the biofabrication of useful structures. Nano-composite bio-inks can create scaffolds that instruct cell behavior and allow for high-quality imaging. Additionally, incorporating nanoparticles into 3D printed configurations can make these structures responsive to external physical stimuli, enhancing their potential in healthcare applications. The study highlights the development of biological systems with functionalities such as motion, shape change, and sensing, emphasizing the promise of nanobiomaterials in tissue regeneration strategies.