The article discusses the redesign of the NCBI BLAST web interface to enhance usability and performance. Key improvements include simplified search forms, improved navigation, a list of recent BLAST results, saved search strategies, and a documentation directory. The redesign addresses previous usability issues such as inconsistent form design, difficult navigation, and lack of recent search history. The new interface features a consistent design with tabs for home, saved strategies, recent results, and help. Users can save search parameters, view and edit results, and access formatting controls. Future plans include better integration of BLAST databases, more reporting options, support for batch operations, and improved interpretation tools. The authors welcome user feedback and contributions to further enhance the BLAST tool.The article discusses the redesign of the NCBI BLAST web interface to enhance usability and performance. Key improvements include simplified search forms, improved navigation, a list of recent BLAST results, saved search strategies, and a documentation directory. The redesign addresses previous usability issues such as inconsistent form design, difficult navigation, and lack of recent search history. The new interface features a consistent design with tabs for home, saved strategies, recent results, and help. Users can save search parameters, view and edit results, and access formatting controls. Future plans include better integration of BLAST databases, more reporting options, support for batch operations, and improved interpretation tools. The authors welcome user feedback and contributions to further enhance the BLAST tool.