The article discusses the role of the transcription factor NF-κB in the development of metabolic diseases, including obesity, type 2 diabetes, and atherosclerosis. NF-κB plays a central role in coordinating inflammatory responses, and its activation is linked to chronic low-grade inflammation, which is a key factor in the initiation and progression of these diseases. The review highlights how NF-κB signaling pathways are activated in various cell types, such as adipocytes, macrophages, and endothelial cells, and how these pathways contribute to the pathophysiology of metabolic disorders. Key findings include the involvement of NF-κB in the recruitment and activation of macrophages, the regulation of inflammatory cytokines, and the coordination of metabolic stress responses. The article also explores the potential therapeutic targets for modulating NF-κB signaling to treat metabolic diseases.The article discusses the role of the transcription factor NF-κB in the development of metabolic diseases, including obesity, type 2 diabetes, and atherosclerosis. NF-κB plays a central role in coordinating inflammatory responses, and its activation is linked to chronic low-grade inflammation, which is a key factor in the initiation and progression of these diseases. The review highlights how NF-κB signaling pathways are activated in various cell types, such as adipocytes, macrophages, and endothelial cells, and how these pathways contribute to the pathophysiology of metabolic disorders. Key findings include the involvement of NF-κB in the recruitment and activation of macrophages, the regulation of inflammatory cytokines, and the coordination of metabolic stress responses. The article also explores the potential therapeutic targets for modulating NF-κB signaling to treat metabolic diseases.