This review provides an overview of the current knowledge on the application of natural deep eutectic solvents (NaDES) in the cosmetic and pharmaceutical fields. NaDES are a new generation of green, non-flammable solvents that offer an efficient alternative to ionic liquids. They are easy to prepare, exhibit strong solubilizing power for lipophilic molecules, and are particularly useful for sustainable extraction, the development of ready-to-use ingredients, and the creation of biocompatible drug delivery systems. In the biomedical field, NaDES can act as biopolymer modifiers and delivery compounds, solubilizing and stabilizing various chemical and galenical formulations. The review highlights the advantages of NaDES over conventional solvents, including their natural origin, low cost, biodegradability, and absence of toxicity. It discusses the preparation methods of NaDES, such as heating and stirring, microwave-assisted preparation, and vacuum evaporation, emphasizing their ease of use and high purity. The structure and properties of NaDES are influenced by the type and ratio of components, as well as the hydrogen bonds formed between metabolites. The application of NaDES in cosmetic and pharmaceutical fields is explored through various studies. In cosmetics, NaDES have been used to extract bioactive compounds from natural sources, such as catechins from green tea leaves, polyphenols from tomato pomace, and flavonoids from plantago major. These extracts are then incorporated into cosmetic formulations, demonstrating their effectiveness in improving skin health and providing anti-aging, UV-protective, and preservative properties. In the pharmaceutical field, NaDES have been utilized to solubilize and stabilize a wide range of pharmaceutical systems, including hydrogels and film formation. They have also been used to deliver bioactive compounds in innovative formulations, such as drug delivery systems for poorly water-soluble drugs and wound dressings. Studies have shown that NaDES can enhance the solubility and stability of drugs, improve the bioavailability of active ingredients, and exhibit antimicrobial and antifungal activities. The review concludes by discussing the potential of NaDES as green solvents in industrial extraction processes, highlighting their versatility, safety, biodegradability, and biocompatibility. Despite some challenges, such as high viscosity and solute separation, the use of NaDES in cosmetic and pharmaceutical applications shows promising opportunities and challenges for future research and development.This review provides an overview of the current knowledge on the application of natural deep eutectic solvents (NaDES) in the cosmetic and pharmaceutical fields. NaDES are a new generation of green, non-flammable solvents that offer an efficient alternative to ionic liquids. They are easy to prepare, exhibit strong solubilizing power for lipophilic molecules, and are particularly useful for sustainable extraction, the development of ready-to-use ingredients, and the creation of biocompatible drug delivery systems. In the biomedical field, NaDES can act as biopolymer modifiers and delivery compounds, solubilizing and stabilizing various chemical and galenical formulations. The review highlights the advantages of NaDES over conventional solvents, including their natural origin, low cost, biodegradability, and absence of toxicity. It discusses the preparation methods of NaDES, such as heating and stirring, microwave-assisted preparation, and vacuum evaporation, emphasizing their ease of use and high purity. The structure and properties of NaDES are influenced by the type and ratio of components, as well as the hydrogen bonds formed between metabolites. The application of NaDES in cosmetic and pharmaceutical fields is explored through various studies. In cosmetics, NaDES have been used to extract bioactive compounds from natural sources, such as catechins from green tea leaves, polyphenols from tomato pomace, and flavonoids from plantago major. These extracts are then incorporated into cosmetic formulations, demonstrating their effectiveness in improving skin health and providing anti-aging, UV-protective, and preservative properties. In the pharmaceutical field, NaDES have been utilized to solubilize and stabilize a wide range of pharmaceutical systems, including hydrogels and film formation. They have also been used to deliver bioactive compounds in innovative formulations, such as drug delivery systems for poorly water-soluble drugs and wound dressings. Studies have shown that NaDES can enhance the solubility and stability of drugs, improve the bioavailability of active ingredients, and exhibit antimicrobial and antifungal activities. The review concludes by discussing the potential of NaDES as green solvents in industrial extraction processes, highlighting their versatility, safety, biodegradability, and biocompatibility. Despite some challenges, such as high viscosity and solute separation, the use of NaDES in cosmetic and pharmaceutical applications shows promising opportunities and challenges for future research and development.