Nanocrystal technology has significantly impacted various fields, including medicine and pharmacy, by enabling the development of new formulations for poorly soluble drugs. Drug nanocrystals, which are nanoparticles with a crystalline structure, have been commercially available for some time. They offer enhanced bioavailability and solubility by increasing the surface area and saturation solubility of drugs. The production of nanocrystals involves technologies such as pearl milling and high-pressure homogenization, which reduce particle size to the nanometer range. These nanocrystals can be used in various formulations, including oral suspensions, tablets, and injectable solutions, to improve drug delivery and clinical outcomes. Nanocrystals enhance dissolution velocity and bioavailability by increasing surface area and saturation solubility. This is particularly beneficial for drugs with poor solubility, as it allows for better absorption and distribution in the body. The use of nanocrystals also reduces the need for surfactants and other additives that may cause side effects. Additionally, nanocrystals can be formulated in a way that allows for controlled release, improving the therapeutic effect and reducing adverse reactions. Several drugs, including Rapamune, Emend, Tricor, and Megace ES, have been successfully formulated using nanocrystal technology. These products demonstrate the effectiveness of nanocrystals in improving bioavailability and reducing side effects. Other drugs in clinical development, such as Semapimod, PAXCEED, Theralux, and NUCRYST, are also being evaluated for their potential benefits in treating various conditions. The advantages of nanocrystal technology include improved solubility, enhanced bioavailability, and reduced side effects. However, challenges remain in terms of production efficiency and the need for specialized formulations to ensure the stability and effectiveness of nanocrystals in different delivery systems. Despite these challenges, nanocrystal technology holds great promise for the future of drug delivery, particularly for drugs with poor solubility and narrow therapeutic windows. The continued development of nanocrystal technology is expected to lead to more effective and safer treatments for a wide range of diseases.Nanocrystal technology has significantly impacted various fields, including medicine and pharmacy, by enabling the development of new formulations for poorly soluble drugs. Drug nanocrystals, which are nanoparticles with a crystalline structure, have been commercially available for some time. They offer enhanced bioavailability and solubility by increasing the surface area and saturation solubility of drugs. The production of nanocrystals involves technologies such as pearl milling and high-pressure homogenization, which reduce particle size to the nanometer range. These nanocrystals can be used in various formulations, including oral suspensions, tablets, and injectable solutions, to improve drug delivery and clinical outcomes. Nanocrystals enhance dissolution velocity and bioavailability by increasing surface area and saturation solubility. This is particularly beneficial for drugs with poor solubility, as it allows for better absorption and distribution in the body. The use of nanocrystals also reduces the need for surfactants and other additives that may cause side effects. Additionally, nanocrystals can be formulated in a way that allows for controlled release, improving the therapeutic effect and reducing adverse reactions. Several drugs, including Rapamune, Emend, Tricor, and Megace ES, have been successfully formulated using nanocrystal technology. These products demonstrate the effectiveness of nanocrystals in improving bioavailability and reducing side effects. Other drugs in clinical development, such as Semapimod, PAXCEED, Theralux, and NUCRYST, are also being evaluated for their potential benefits in treating various conditions. The advantages of nanocrystal technology include improved solubility, enhanced bioavailability, and reduced side effects. However, challenges remain in terms of production efficiency and the need for specialized formulations to ensure the stability and effectiveness of nanocrystals in different delivery systems. Despite these challenges, nanocrystal technology holds great promise for the future of drug delivery, particularly for drugs with poor solubility and narrow therapeutic windows. The continued development of nanocrystal technology is expected to lead to more effective and safer treatments for a wide range of diseases.