This study provides an overview of the major nanopharmaceutical formulations and the impact of nanotechnology on the future of pharmaceuticals. It highlights the importance of eco-friendly and natural resource-based strategies for designing new nanoformulations with therapeutic efficiency. The paper discusses modern approaches to designing pharmaceutical nanoformulations, such as 3D printing, phyto-nanotechnology, and biomimetics/bioinspiration. It emphasizes the need for careful consideration of safety and long-term effects in the preparation of nanomaterials. The testing of nanopharmaceuticals is crucial for their further applications. Vegetal scaffolds obtained by decellularizing plant leaves are presented as a valuable, bioinspired model for nanopharmaceutical testing that avoids animal use. Nanoformulations are critical in various fields, including pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations. These advantages include improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields such as cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. The study also discusses the challenges, opportunities, and future directions in the field of nanopharmaceuticals.This study provides an overview of the major nanopharmaceutical formulations and the impact of nanotechnology on the future of pharmaceuticals. It highlights the importance of eco-friendly and natural resource-based strategies for designing new nanoformulations with therapeutic efficiency. The paper discusses modern approaches to designing pharmaceutical nanoformulations, such as 3D printing, phyto-nanotechnology, and biomimetics/bioinspiration. It emphasizes the need for careful consideration of safety and long-term effects in the preparation of nanomaterials. The testing of nanopharmaceuticals is crucial for their further applications. Vegetal scaffolds obtained by decellularizing plant leaves are presented as a valuable, bioinspired model for nanopharmaceutical testing that avoids animal use. Nanoformulations are critical in various fields, including pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations. These advantages include improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields such as cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. The study also discusses the challenges, opportunities, and future directions in the field of nanopharmaceuticals.