Nanogels are swollen, nano-sized polymer networks composed of hydrophilic or amphiphilic chains, capable of delivering drugs and biomacromolecules. They can absorb biological agents through salt, hydrogen, or hydrophobic interactions, leading to high loading capacities and stability. Nanogels can be designed to release drugs in response to environmental factors like pH, temperature, or ionic strength. They are used for drug delivery, imaging, and targeted therapies, including anticancer and antiviral treatments. Recent studies show their potential in delivering nucleoside analogs, siRNA, proteins, and other biomacromolecules. Nanogels can be functionalized with targeting ligands, stimuli-responsive cross-links, or imaging agents. They are also used in composite materials, nanometallic or nanoceramic structures, and for enhancing oral and CNS drug delivery. Nanogels can be synthesized through physical self-assembly, polymerization, chemical cross-linking, or template-assisted methods. They are highly responsive to environmental stimuli and can be modified for targeted delivery, drug release, or composite material formation. Preclinical studies suggest their effectiveness in delivering biopharmaceuticals and enhancing drug delivery across cellular barriers. Nanogels offer a versatile platform for drug delivery, with potential applications in gene therapy, vaccine development, and targeted therapies. Their unique properties, including high loading capacity, stability, and responsiveness, make them promising pharmaceutical carriers for future drug delivery systems.Nanogels are swollen, nano-sized polymer networks composed of hydrophilic or amphiphilic chains, capable of delivering drugs and biomacromolecules. They can absorb biological agents through salt, hydrogen, or hydrophobic interactions, leading to high loading capacities and stability. Nanogels can be designed to release drugs in response to environmental factors like pH, temperature, or ionic strength. They are used for drug delivery, imaging, and targeted therapies, including anticancer and antiviral treatments. Recent studies show their potential in delivering nucleoside analogs, siRNA, proteins, and other biomacromolecules. Nanogels can be functionalized with targeting ligands, stimuli-responsive cross-links, or imaging agents. They are also used in composite materials, nanometallic or nanoceramic structures, and for enhancing oral and CNS drug delivery. Nanogels can be synthesized through physical self-assembly, polymerization, chemical cross-linking, or template-assisted methods. They are highly responsive to environmental stimuli and can be modified for targeted delivery, drug release, or composite material formation. Preclinical studies suggest their effectiveness in delivering biopharmaceuticals and enhancing drug delivery across cellular barriers. Nanogels offer a versatile platform for drug delivery, with potential applications in gene therapy, vaccine development, and targeted therapies. Their unique properties, including high loading capacity, stability, and responsiveness, make them promising pharmaceutical carriers for future drug delivery systems.