Nanomaterials in the Wound Healing Process: New Insights and Advancements Wounds, caused by trauma, surgery, burns, and chronic diseases like diabetes, remain a critical medical issue. Infectious bacteria, especially those forming biofilms, can delay healing and cause chronic infections. Nanomaterials, with their unique properties and versatile applications, have emerged as promising candidates for wound healing. However, research on their effectiveness in promoting wound healing is limited. This review outlines various nanomaterials studied for wound healing and infection prevention, highlighting their potential in developing effective wound care therapies. Wound healing involves multiple stages: hemostasis, inflammation, proliferation, and maturation. Each stage is influenced by factors such as the patient's environment and condition. Nanomaterials can influence these stages by promoting cell growth, reducing inflammation, and enhancing tissue repair. Different types of nanomaterials, including metal nanoparticles, carbon-based nanomaterials, and hydrogels, have shown promise in wound healing. For example, silver nanoparticles promote fibroblast differentiation and keratinocyte proliferation, while zinc oxide nanoparticles exhibit antibacterial and photo-oxidation properties. Gold nanoparticles enhance collagen deposition and accelerate wound healing. Carbon nanotubes, including single-walled, double-walled, and multi-walled nanotubes, have shown antibacterial activity and potential in tissue engineering. Nanomaterials are also used as drug carriers, delivering antimicrobial agents directly to the wound site. Liposomal delivery systems and nanohydrogels have been developed to improve drug release and wound healing. Metal-based nanoparticles, such as silver and zinc oxide, are effective against bacteria due to their ability to induce oxidative stress and disrupt bacterial cell membranes. However, their use must be carefully managed to avoid toxicity and resistance. This review highlights the potential of nanomaterials in wound healing, emphasizing their ability to enhance healing processes, reduce inflammation, and prevent infections. Despite their promise, further research is needed to fully understand their mechanisms and optimize their use in clinical settings. The integration of nanomaterials into wound care therapies offers new opportunities for more effective and efficient treatments.Nanomaterials in the Wound Healing Process: New Insights and Advancements Wounds, caused by trauma, surgery, burns, and chronic diseases like diabetes, remain a critical medical issue. Infectious bacteria, especially those forming biofilms, can delay healing and cause chronic infections. Nanomaterials, with their unique properties and versatile applications, have emerged as promising candidates for wound healing. However, research on their effectiveness in promoting wound healing is limited. This review outlines various nanomaterials studied for wound healing and infection prevention, highlighting their potential in developing effective wound care therapies. Wound healing involves multiple stages: hemostasis, inflammation, proliferation, and maturation. Each stage is influenced by factors such as the patient's environment and condition. Nanomaterials can influence these stages by promoting cell growth, reducing inflammation, and enhancing tissue repair. Different types of nanomaterials, including metal nanoparticles, carbon-based nanomaterials, and hydrogels, have shown promise in wound healing. For example, silver nanoparticles promote fibroblast differentiation and keratinocyte proliferation, while zinc oxide nanoparticles exhibit antibacterial and photo-oxidation properties. Gold nanoparticles enhance collagen deposition and accelerate wound healing. Carbon nanotubes, including single-walled, double-walled, and multi-walled nanotubes, have shown antibacterial activity and potential in tissue engineering. Nanomaterials are also used as drug carriers, delivering antimicrobial agents directly to the wound site. Liposomal delivery systems and nanohydrogels have been developed to improve drug release and wound healing. Metal-based nanoparticles, such as silver and zinc oxide, are effective against bacteria due to their ability to induce oxidative stress and disrupt bacterial cell membranes. However, their use must be carefully managed to avoid toxicity and resistance. This review highlights the potential of nanomaterials in wound healing, emphasizing their ability to enhance healing processes, reduce inflammation, and prevent infections. Despite their promise, further research is needed to fully understand their mechanisms and optimize their use in clinical settings. The integration of nanomaterials into wound care therapies offers new opportunities for more effective and efficient treatments.