Wounds, increasingly common due to traumas, surgeries, burns, and chronic illnesses like diabetes, remain a critical medical challenge. Infectious bacteria, particularly biofilms, can prolong healing and lead to chronic infections. Nanomaterials (NMs) have emerged as promising candidates in wound healing due to their unique properties and versatile applications. This review explores various types of NMs studied for wound healing and infection prevention, highlighting their therapeutic mechanisms and potential benefits. However, limited research has focused on the significant promotion of wound healing by these materials. The utilization of NMs in wound healing holds great promise, offering new opportunities for effective and efficient wound care therapies. The skin, a vital organ, is susceptible to various injuries, and the World Health Organization (WHO) reports that burn wounds alone cause over 300,000 fatalities annually. Wound healing is a complex process involving hemostasis, inflammation, proliferation, and maturation. Traditional antibacterial treatments face challenges due to antimicrobial resistance (AMR) and multidrug resistance (MDR), which pose serious therapeutic issues. NMs, particularly nanoparticles, have gained attention for their potential to enhance wound healing and manage infections. Nanoparticles, with their high surface area-to-volume ratio, are well-suited for wound dressing applications. Metal nanoparticles like silver, gold, and zinc are effective due to their antibacterial properties and wound healing stimulation. For instance, silver nanoparticles promote keratinocyte proliferation and reduce inflammation, while gold nanoparticles enhance keratinocyte development and differentiation. Zinc oxide nanoparticles (ZnONPs) act as potent antibacterial agents by triggering bacterial cell membrane perforations and increasing contact time with keratinocytes. Carbon-based nanomaterials, such as carbon nanotubes (CNTs), also show promise. CNTs, including single-walled, double-walled, and multi-walled varieties, exhibit excellent mechanical, thermal, and electrical properties. They have been shown to have broad antibacterial activity and can be used in biomedicine. Liposomal delivery systems and nanohydrogels are other innovative approaches that enhance the efficacy of NMs in wound healing. Metal nanoparticles (MBNPs) and biomaterials are also explored for their antibacterial and wound healing properties. MBNPs, such as silver and zinc oxide nanoparticles, can induce oxidative stress and disrupt bacterial membranes, leading to cell death. Biomaterials made from metals, including angstrom-scale materials and metal quantum dots, show potent antibacterial effects and are used in wound repair. Overall, the integration of NMs into wound healing therapies holds significant promise, offering new avenues for effective and efficient wound care. However, further research is needed to fully understand the fundamental processes and cellular cascades to tailor NMs for specific wound healing needs.Wounds, increasingly common due to traumas, surgeries, burns, and chronic illnesses like diabetes, remain a critical medical challenge. Infectious bacteria, particularly biofilms, can prolong healing and lead to chronic infections. Nanomaterials (NMs) have emerged as promising candidates in wound healing due to their unique properties and versatile applications. This review explores various types of NMs studied for wound healing and infection prevention, highlighting their therapeutic mechanisms and potential benefits. However, limited research has focused on the significant promotion of wound healing by these materials. The utilization of NMs in wound healing holds great promise, offering new opportunities for effective and efficient wound care therapies. The skin, a vital organ, is susceptible to various injuries, and the World Health Organization (WHO) reports that burn wounds alone cause over 300,000 fatalities annually. Wound healing is a complex process involving hemostasis, inflammation, proliferation, and maturation. Traditional antibacterial treatments face challenges due to antimicrobial resistance (AMR) and multidrug resistance (MDR), which pose serious therapeutic issues. NMs, particularly nanoparticles, have gained attention for their potential to enhance wound healing and manage infections. Nanoparticles, with their high surface area-to-volume ratio, are well-suited for wound dressing applications. Metal nanoparticles like silver, gold, and zinc are effective due to their antibacterial properties and wound healing stimulation. For instance, silver nanoparticles promote keratinocyte proliferation and reduce inflammation, while gold nanoparticles enhance keratinocyte development and differentiation. Zinc oxide nanoparticles (ZnONPs) act as potent antibacterial agents by triggering bacterial cell membrane perforations and increasing contact time with keratinocytes. Carbon-based nanomaterials, such as carbon nanotubes (CNTs), also show promise. CNTs, including single-walled, double-walled, and multi-walled varieties, exhibit excellent mechanical, thermal, and electrical properties. They have been shown to have broad antibacterial activity and can be used in biomedicine. Liposomal delivery systems and nanohydrogels are other innovative approaches that enhance the efficacy of NMs in wound healing. Metal nanoparticles (MBNPs) and biomaterials are also explored for their antibacterial and wound healing properties. MBNPs, such as silver and zinc oxide nanoparticles, can induce oxidative stress and disrupt bacterial membranes, leading to cell death. Biomaterials made from metals, including angstrom-scale materials and metal quantum dots, show potent antibacterial effects and are used in wound repair. Overall, the integration of NMs into wound healing therapies holds significant promise, offering new avenues for effective and efficient wound care. However, further research is needed to fully understand the fundamental processes and cellular cascades to tailor NMs for specific wound healing needs.