This article provides an overview of nanotechnology in drug delivery, particularly focusing on the novel XPclad® nanoparticle formulation. Nanotechnology, defined as the manipulation and study of structures and devices at the nanometer scale, offers significant advantages in drug delivery due to its ability to interact with complex cellular functions. Nanoparticles, such as XPclad®, are characterized by their small size, customized surface properties, improved solubility, and multifunctionality, making them effective for targeted drug delivery, diagnosis, and treatment of diseases like cancer. The article discusses the attributes of XPclad® nanoparticles, including their efficacy in treating solid tumors, single-dose vaccination, and oral delivery of therapeutic proteins. It also highlights the importance of particle size, surface properties, drug loading, and release mechanisms in the design of effective nanodelivery systems. The potential of nanotechnology in overcoming drug resistance and facilitating drug delivery across biological barriers is emphasized, along with the challenges and future directions in this field.This article provides an overview of nanotechnology in drug delivery, particularly focusing on the novel XPclad® nanoparticle formulation. Nanotechnology, defined as the manipulation and study of structures and devices at the nanometer scale, offers significant advantages in drug delivery due to its ability to interact with complex cellular functions. Nanoparticles, such as XPclad®, are characterized by their small size, customized surface properties, improved solubility, and multifunctionality, making them effective for targeted drug delivery, diagnosis, and treatment of diseases like cancer. The article discusses the attributes of XPclad® nanoparticles, including their efficacy in treating solid tumors, single-dose vaccination, and oral delivery of therapeutic proteins. It also highlights the importance of particle size, surface properties, drug loading, and release mechanisms in the design of effective nanodelivery systems. The potential of nanotechnology in overcoming drug resistance and facilitating drug delivery across biological barriers is emphasized, along with the challenges and future directions in this field.