Nanotechnology shows promise in treating skin cancer by improving drug delivery and treatment efficacy. Skin cancer includes non-melanoma (BCC, SCC) and melanoma, with melanoma being more aggressive and deadly. Risk factors include UV exposure, genetic predisposition, and environmental factors. UV radiation causes photoaging, leading to skin damage and cancer development. Melanoma incidence has risen, particularly in light-skinned individuals. Nanotechnology offers innovative approaches for early detection and targeted treatment. Nanoparticles, such as liposomes, carbon nanotubes, and polymer nanoparticles, enhance drug delivery, reduce side effects, and improve therapeutic outcomes. Liposomes, for example, can deliver chemotherapy agents more effectively, increasing their bioavailability and reducing toxicity. Ethosomes and solid lipid nanoparticles also show potential in improving drug penetration and retention. Inorganic nanoparticles, including gold and silver, are used for targeted drug delivery and photodynamic therapy. These nanoparticles can enhance the effectiveness of chemotherapy and reduce systemic toxicity. Carbon nanotubes and nanofibers offer targeted delivery and improved penetration into cancer cells. Polymer-based nanoparticles, such as polymeric nanocarriers, provide controlled drug release and enhanced tumor targeting. Overall, nanotechnology holds significant potential for improving skin cancer treatment by enhancing drug delivery, reducing side effects, and increasing therapeutic efficacy. Further research is needed to optimize these technologies for clinical application.Nanotechnology shows promise in treating skin cancer by improving drug delivery and treatment efficacy. Skin cancer includes non-melanoma (BCC, SCC) and melanoma, with melanoma being more aggressive and deadly. Risk factors include UV exposure, genetic predisposition, and environmental factors. UV radiation causes photoaging, leading to skin damage and cancer development. Melanoma incidence has risen, particularly in light-skinned individuals. Nanotechnology offers innovative approaches for early detection and targeted treatment. Nanoparticles, such as liposomes, carbon nanotubes, and polymer nanoparticles, enhance drug delivery, reduce side effects, and improve therapeutic outcomes. Liposomes, for example, can deliver chemotherapy agents more effectively, increasing their bioavailability and reducing toxicity. Ethosomes and solid lipid nanoparticles also show potential in improving drug penetration and retention. Inorganic nanoparticles, including gold and silver, are used for targeted drug delivery and photodynamic therapy. These nanoparticles can enhance the effectiveness of chemotherapy and reduce systemic toxicity. Carbon nanotubes and nanofibers offer targeted delivery and improved penetration into cancer cells. Polymer-based nanoparticles, such as polymeric nanocarriers, provide controlled drug release and enhanced tumor targeting. Overall, nanotechnology holds significant potential for improving skin cancer treatment by enhancing drug delivery, reducing side effects, and increasing therapeutic efficacy. Further research is needed to optimize these technologies for clinical application.