The incidence of skin cancer, particularly melanoma, is increasing globally, with an estimated 1.5 million new cases annually. Conventional treatments, such as chemotherapy, are often ineffective and have limited efficacy. Nanotechnology offers a promising solution by enabling early detection, monitoring neoplastic changes, and improving treatment effectiveness. This article reviews the characteristics of skin cancers, their epidemiology, and risk factors, and discusses the potential of nanotechnology in drug delivery. Liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles are highlighted for their ability to enhance drug delivery to cancer cells, reduce side effects, and improve therapeutic outcomes. The use of nanotechnology is seen as a significant advancement in the fight against skin cancer, offering more precise and less toxic treatments.The incidence of skin cancer, particularly melanoma, is increasing globally, with an estimated 1.5 million new cases annually. Conventional treatments, such as chemotherapy, are often ineffective and have limited efficacy. Nanotechnology offers a promising solution by enabling early detection, monitoring neoplastic changes, and improving treatment effectiveness. This article reviews the characteristics of skin cancers, their epidemiology, and risk factors, and discusses the potential of nanotechnology in drug delivery. Liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles are highlighted for their ability to enhance drug delivery to cancer cells, reduce side effects, and improve therapeutic outcomes. The use of nanotechnology is seen as a significant advancement in the fight against skin cancer, offering more precise and less toxic treatments.