The review discusses the nose-to-brain drug-delivery system, a promising strategy for treating central nervous system disorders by overcoming the blood-brain barrier (BBB). The nasal cavity's high permeability and rich blood supply facilitate rapid drug absorption and onset of action, making it a promising domain for neurological therapeutics. The article explores various nanocarriers such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, micelles, nanoemulsions, nanosuspensions, carbon nanotubes, mesoporous silica nanoparticles, and nanogels, highlighting their diverse functions in improving drug delivery efficiency and targeting specificity. To minimize nanoparticle-induced toxicity, the review also covers recent advancements in formulation strategies, including surface modifications, cutting-edge materials, and novel formulations to enhance drug stability, release kinetics, and targeting specificity. These approaches aim to enhance drug absorption while minimizing adverse effects, potentially revolutionizing treatments for neurological disorders. The review provides valuable insights for researchers, clinicians, and pharmaceutical professionals seeking to advance the development of effective and safe therapies for central nervous system disorders.The review discusses the nose-to-brain drug-delivery system, a promising strategy for treating central nervous system disorders by overcoming the blood-brain barrier (BBB). The nasal cavity's high permeability and rich blood supply facilitate rapid drug absorption and onset of action, making it a promising domain for neurological therapeutics. The article explores various nanocarriers such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, micelles, nanoemulsions, nanosuspensions, carbon nanotubes, mesoporous silica nanoparticles, and nanogels, highlighting their diverse functions in improving drug delivery efficiency and targeting specificity. To minimize nanoparticle-induced toxicity, the review also covers recent advancements in formulation strategies, including surface modifications, cutting-edge materials, and novel formulations to enhance drug stability, release kinetics, and targeting specificity. These approaches aim to enhance drug absorption while minimizing adverse effects, potentially revolutionizing treatments for neurological disorders. The review provides valuable insights for researchers, clinicians, and pharmaceutical professionals seeking to advance the development of effective and safe therapies for central nervous system disorders.