This study provides a comprehensive analysis of human salmonellosis outbreaks in China, covering 74 years and 1,134 reports involving 89,050 patients and 270 deaths. The research reveals a rising trend in the number of salmonellosis outbreaks since the 1970s, with most outbreaks occurring east of the Hu line, particularly in coastal and populated regions. The overall attack rate is estimated at 36.66%, and antimicrobial resistance to quinolones (49.51%) and beta-lactams (73.76%) remains high. The study also highlights the need for further attention to healthcare-associated salmonellosis (HAI) and the development of an online database, the Chinese Salmonellosis Outbreak Database (CSOD), for data sharing and visualization. The findings indicate that HAI requires special attention due to its higher fatality rate and potential for antimicrobial resistance. The study's insights contribute to the development of more effective control strategies for salmonellosis in China and other developing countries.This study provides a comprehensive analysis of human salmonellosis outbreaks in China, covering 74 years and 1,134 reports involving 89,050 patients and 270 deaths. The research reveals a rising trend in the number of salmonellosis outbreaks since the 1970s, with most outbreaks occurring east of the Hu line, particularly in coastal and populated regions. The overall attack rate is estimated at 36.66%, and antimicrobial resistance to quinolones (49.51%) and beta-lactams (73.76%) remains high. The study also highlights the need for further attention to healthcare-associated salmonellosis (HAI) and the development of an online database, the Chinese Salmonellosis Outbreak Database (CSOD), for data sharing and visualization. The findings indicate that HAI requires special attention due to its higher fatality rate and potential for antimicrobial resistance. The study's insights contribute to the development of more effective control strategies for salmonellosis in China and other developing countries.