This review discusses the latest advancements in natural regenerative hydrogels used for wound healing, focusing on their chemical composition, cross-linking mechanisms, and functional properties. Key carbohydrate polymers such as alginate, chitosan, hyaluronic acid, and polysaccharide gums (agarose, carrageenan, xanthan gum) are highlighted for their sources, chemical structures, and specific properties suitable for regenerative applications. The review categorizes hydrogels based on ionic charge, response to physiological stimuli (pH, temperature), and their roles in wound tissue self-healing. Various methods of cross-linking, including physical and chemical approaches, are examined to enhance the mechanical and biological performance of these hydrogels. The article also explores the potential of natural hydrogels to revolutionize regenerative medicine and improve patient healing outcomes, emphasizing recent innovations and ongoing challenges.This review discusses the latest advancements in natural regenerative hydrogels used for wound healing, focusing on their chemical composition, cross-linking mechanisms, and functional properties. Key carbohydrate polymers such as alginate, chitosan, hyaluronic acid, and polysaccharide gums (agarose, carrageenan, xanthan gum) are highlighted for their sources, chemical structures, and specific properties suitable for regenerative applications. The review categorizes hydrogels based on ionic charge, response to physiological stimuli (pH, temperature), and their roles in wound tissue self-healing. Various methods of cross-linking, including physical and chemical approaches, are examined to enhance the mechanical and biological performance of these hydrogels. The article also explores the potential of natural hydrogels to revolutionize regenerative medicine and improve patient healing outcomes, emphasizing recent innovations and ongoing challenges.