The article reviews the potential therapeutic applications of three natural products—bee venom (BV), *Ficus carica* (FC), and *Geranium* essential oil (GEO)—in treating various skin conditions and promoting skin care. These products have common pharmacological actions, including anti-inflammatory, antibacterial, and antioxidant properties. The study focuses on the safety of topical use and new approaches to these natural therapeutic agents. The review highlights their effectiveness in treating conditions such as vitiligo, melasma, and melanoma, as well as their use in dermatological conditions in patients with diabetes. Key findings include: 1. **Atopic Dermatitis**: BV and FC have shown beneficial effects in reducing symptoms and improving skin conditions. BV has been found to suppress inflammatory cytokines and modulate the complement system, while FC has demonstrated superior safety and efficacy compared to conventional treatments. 2. **Acne**: BV and GEO have antimicrobial and anti-inflammatory properties, reducing acne lesions and improving skin conditions. BV has been shown to inhibit the growth of *Propionibacterium acnes* and reduce inflammatory cytokines, while GEO helps regulate sebum production and improve skin circulation. 3. **Psoriasis**: BV and FC have been studied for their potential in treating psoriasis. BV has shown significant improvements in skin thickness and inflammatory markers, while FC has reduced nitric oxide production and iNOS and COX-2 expression, indicating its potential as a therapeutic agent. 4. **Wound Healing**: BV and GEO have been effective in accelerating wound healing, particularly in diabetic patients. BV has been shown to increase collagen production and improve angiogenesis, while GEO has demonstrated antibacterial activity against Gram-negative bacteria. 5. **Alopecia**: BV and FC have been explored for their potential in treating hair loss. BV has been found to improve hair follicle development and stimulate growth factors, while FC has shown promise in promoting hair growth through encapsulation in nanoparticles. 6. **Wrinkles**: BV, FC, and GEO have demonstrated anti-wrinkle effects. BV has been shown to reduce the depth and number of wrinkles, while FC and GEO have demonstrated antioxidant and anti-collagenase activities, contributing to skin rejuvenation. The article emphasizes the potential of these natural products as safe and effective alternatives to conventional treatments, highlighting their broad therapeutic applications in dermatology.The article reviews the potential therapeutic applications of three natural products—bee venom (BV), *Ficus carica* (FC), and *Geranium* essential oil (GEO)—in treating various skin conditions and promoting skin care. These products have common pharmacological actions, including anti-inflammatory, antibacterial, and antioxidant properties. The study focuses on the safety of topical use and new approaches to these natural therapeutic agents. The review highlights their effectiveness in treating conditions such as vitiligo, melasma, and melanoma, as well as their use in dermatological conditions in patients with diabetes. Key findings include: 1. **Atopic Dermatitis**: BV and FC have shown beneficial effects in reducing symptoms and improving skin conditions. BV has been found to suppress inflammatory cytokines and modulate the complement system, while FC has demonstrated superior safety and efficacy compared to conventional treatments. 2. **Acne**: BV and GEO have antimicrobial and anti-inflammatory properties, reducing acne lesions and improving skin conditions. BV has been shown to inhibit the growth of *Propionibacterium acnes* and reduce inflammatory cytokines, while GEO helps regulate sebum production and improve skin circulation. 3. **Psoriasis**: BV and FC have been studied for their potential in treating psoriasis. BV has shown significant improvements in skin thickness and inflammatory markers, while FC has reduced nitric oxide production and iNOS and COX-2 expression, indicating its potential as a therapeutic agent. 4. **Wound Healing**: BV and GEO have been effective in accelerating wound healing, particularly in diabetic patients. BV has been shown to increase collagen production and improve angiogenesis, while GEO has demonstrated antibacterial activity against Gram-negative bacteria. 5. **Alopecia**: BV and FC have been explored for their potential in treating hair loss. BV has been found to improve hair follicle development and stimulate growth factors, while FC has shown promise in promoting hair growth through encapsulation in nanoparticles. 6. **Wrinkles**: BV, FC, and GEO have demonstrated anti-wrinkle effects. BV has been shown to reduce the depth and number of wrinkles, while FC and GEO have demonstrated antioxidant and anti-collagenase activities, contributing to skin rejuvenation. The article emphasizes the potential of these natural products as safe and effective alternatives to conventional treatments, highlighting their broad therapeutic applications in dermatology.