The article reviews the latest discoveries in three well-understood modalities of cell death: apoptosis, necroptosis, and pyroptosis. It highlights the common and unique pathways and their effects on the surrounding cells and the organism as a whole. Necroptosis, a regulated form of necrosis, is triggered by the activation of death domain receptors and Toll-like receptors, leading to the formation of necrosomes and membrane pores, ultimately causing cell lysis and the release of intracellular contents. Pyroptosis, an inflammatory form of cell death, is induced by inflammasome sensors detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). It involves the activation of caspase-1, which processes cytokines and activates gasdermin D (GSDMD) to form pores in the plasma membrane, leading to cell lysis and cytokine release. Apoptosis, the most studied form of cell death, is regulated by a balance between pro- and antiapoptotic proteins of the BCL-2 family and involves the release of cytochrome c from mitochondria, leading to the formation of apoptosomes and the activation of caspases. The article emphasizes the complex mechanisms and regulatory processes involved in these cell death pathways, highlighting their roles in immune responses, inflammation, and disease development.The article reviews the latest discoveries in three well-understood modalities of cell death: apoptosis, necroptosis, and pyroptosis. It highlights the common and unique pathways and their effects on the surrounding cells and the organism as a whole. Necroptosis, a regulated form of necrosis, is triggered by the activation of death domain receptors and Toll-like receptors, leading to the formation of necrosomes and membrane pores, ultimately causing cell lysis and the release of intracellular contents. Pyroptosis, an inflammatory form of cell death, is induced by inflammasome sensors detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). It involves the activation of caspase-1, which processes cytokines and activates gasdermin D (GSDMD) to form pores in the plasma membrane, leading to cell lysis and cytokine release. Apoptosis, the most studied form of cell death, is regulated by a balance between pro- and antiapoptotic proteins of the BCL-2 family and involves the release of cytochrome c from mitochondria, leading to the formation of apoptosomes and the activation of caspases. The article emphasizes the complex mechanisms and regulatory processes involved in these cell death pathways, highlighting their roles in immune responses, inflammation, and disease development.