The Wiley Online Proofing System enables proof reviewers to review PDF proofs, mark corrections, respond to queries, upload replacement figures, and submit changes directly from the locally saved PDF proof. Key steps include ensuring internet connection, using annotation tools to mark corrections and responses, saving corrections by clicking "Publish Comments," uploading large files via the "Upload Files" button, and completing the proof review by clicking "Complete Proof Review." The system requires Adobe Acrobat Professional or Adobe Reader (version 8.0 or above) for e-Annotating PDFs. The article also discusses the use of network meta-analysis in systematic reviews, highlighting its ability to include both direct and indirect evidence from randomized controlled trials (RCTs) to provide a ranking of treatment approaches. However, it emphasizes the importance of critically evaluating the risk of publication bias and the quality of included RCTs.The Wiley Online Proofing System enables proof reviewers to review PDF proofs, mark corrections, respond to queries, upload replacement figures, and submit changes directly from the locally saved PDF proof. Key steps include ensuring internet connection, using annotation tools to mark corrections and responses, saving corrections by clicking "Publish Comments," uploading large files via the "Upload Files" button, and completing the proof review by clicking "Complete Proof Review." The system requires Adobe Acrobat Professional or Adobe Reader (version 8.0 or above) for e-Annotating PDFs. The article also discusses the use of network meta-analysis in systematic reviews, highlighting its ability to include both direct and indirect evidence from randomized controlled trials (RCTs) to provide a ranking of treatment approaches. However, it emphasizes the importance of critically evaluating the risk of publication bias and the quality of included RCTs.