The article discusses the role of WRKY transcription factors in plant defense signaling. WRKY factors are implicated in the regulation of transcriptional reprogramming associated with plant immune responses. Recent genetic evidence has confirmed their significance as both positive and negative regulators of disease resistance. WRKY genes form a complex network of transcriptional regulation, including positive and negative feedback loops and feed-forward modules. This network allows for efficient and balanced amplification and diversification of defense signals. Key mechanisms triggering strong immune responses involve the inactivation of defense-suppressing WRKY proteins. The article also highlights the functional redundancy among WRKY family members and the conserved structural features that may integrate these factors into the defense network. Additionally, it explores the modular nature of the WRKY web, where specific WRKY proteins play roles in different aspects of defense signaling, such as positive and negative regulation of defense genes. The article concludes by emphasizing the importance of WRKY factors in plant defense and the potential for future discoveries in this area.The article discusses the role of WRKY transcription factors in plant defense signaling. WRKY factors are implicated in the regulation of transcriptional reprogramming associated with plant immune responses. Recent genetic evidence has confirmed their significance as both positive and negative regulators of disease resistance. WRKY genes form a complex network of transcriptional regulation, including positive and negative feedback loops and feed-forward modules. This network allows for efficient and balanced amplification and diversification of defense signals. Key mechanisms triggering strong immune responses involve the inactivation of defense-suppressing WRKY proteins. The article also highlights the functional redundancy among WRKY family members and the conserved structural features that may integrate these factors into the defense network. Additionally, it explores the modular nature of the WRKY web, where specific WRKY proteins play roles in different aspects of defense signaling, such as positive and negative regulation of defense genes. The article concludes by emphasizing the importance of WRKY factors in plant defense and the potential for future discoveries in this area.