The study by Grimm, Hope, Wise, and Shaham investigates the incubation of cocaine craving during the first two months of withdrawal in rats. They used a lever-pressing model to simulate cocaine-seeking behavior, where rats were trained to receive intravenous cocaine injections. After withdrawal, the rats were tested under conditions where the cocaine reward was no longer given. The results showed that lever-pressing dropped to almost zero after a single day of withdrawal but increased progressively over the two-month period, reaching its peak after 60 days. This suggests that craving for cocaine does not decay but rather increases over time, aligning with clinical observations in humans. The findings indicate that a delayed-onset craving syndrome develops during the initial stages of cocaine abstinence and may last longer than previously thought. The mechanisms behind this incubation are not fully understood, but the intensified drug-seeking behavior occurs when most neuroadaptive changes associated with chronic cocaine addiction are in decline.The study by Grimm, Hope, Wise, and Shaham investigates the incubation of cocaine craving during the first two months of withdrawal in rats. They used a lever-pressing model to simulate cocaine-seeking behavior, where rats were trained to receive intravenous cocaine injections. After withdrawal, the rats were tested under conditions where the cocaine reward was no longer given. The results showed that lever-pressing dropped to almost zero after a single day of withdrawal but increased progressively over the two-month period, reaching its peak after 60 days. This suggests that craving for cocaine does not decay but rather increases over time, aligning with clinical observations in humans. The findings indicate that a delayed-onset craving syndrome develops during the initial stages of cocaine abstinence and may last longer than previously thought. The mechanisms behind this incubation are not fully understood, but the intensified drug-seeking behavior occurs when most neuroadaptive changes associated with chronic cocaine addiction are in decline.