The commentary by C. Fine and R. J. R. Blair addresses two main points regarding Depue & Collins's (D&C) target article on the neurobiology of personality, particularly focusing on the role of the orbitofrontal cortex (MOC13) in instrumental conditioning. First, they provide evidence that MOC13 is not essential for instrumental conditioning, contrary to D&C's apparent position. Second, they suggest that integrating formal computational theory, such as Grossberg's adaptive resonance theory (ART), can enhance D&C's approach. The authors argue that D&C's detailed neuroanatomical description of incentive motivation processes fails to account for crucial aspects like the dissociation between instrumental learning and relearning, and the "persistence problem." They propose that Grossberg's model, which includes interactions between attentional and orienting subsystems, can better explain these phenomena. Additionally, they suggest that dopamine may play a key role in facilitating incentive motivation, and that individual differences in sensitivity to different stimuli can be represented by varying responsiveness of drive representations, aligning with Gray's theory of extraversion.The commentary by C. Fine and R. J. R. Blair addresses two main points regarding Depue & Collins's (D&C) target article on the neurobiology of personality, particularly focusing on the role of the orbitofrontal cortex (MOC13) in instrumental conditioning. First, they provide evidence that MOC13 is not essential for instrumental conditioning, contrary to D&C's apparent position. Second, they suggest that integrating formal computational theory, such as Grossberg's adaptive resonance theory (ART), can enhance D&C's approach. The authors argue that D&C's detailed neuroanatomical description of incentive motivation processes fails to account for crucial aspects like the dissociation between instrumental learning and relearning, and the "persistence problem." They propose that Grossberg's model, which includes interactions between attentional and orienting subsystems, can better explain these phenomena. Additionally, they suggest that dopamine may play a key role in facilitating incentive motivation, and that individual differences in sensitivity to different stimuli can be represented by varying responsiveness of drive representations, aligning with Gray's theory of extraversion.