This systematic review aims to investigate the cognitive profile of patients with long-COVID syndrome, defined as symptoms persisting for more than 12 weeks after the onset of COVID-19. The review includes 36 studies published between 2020 and 2023, focusing on cross-sectional and longitudinal empirical studies. The studies consistently report persistent cognitive changes in COVID-19 survivors, with executive function, memory, attention, and processing speed being the most frequently impaired domains. Language impairment, while less studied, is also noted. The review highlights the need for precise identification of factors inducing cognitive impairment in COVID-19 survivors to facilitate early diagnosis and targeted rehabilitation interventions. The findings suggest that cognitive impairment in long-COVID is multifactorial, influenced by factors such as inflammation, sleep disturbances, and sociodemographic characteristics. The review also emphasizes the importance of cultural sensitivity in neuropsychological assessments, given the diverse geographical origins of the included studies. Overall, the evidence supports the widespread occurrence of cognitive impairment in long-COVID, underscoring the need for comprehensive and multidisciplinary evaluations and interventions.This systematic review aims to investigate the cognitive profile of patients with long-COVID syndrome, defined as symptoms persisting for more than 12 weeks after the onset of COVID-19. The review includes 36 studies published between 2020 and 2023, focusing on cross-sectional and longitudinal empirical studies. The studies consistently report persistent cognitive changes in COVID-19 survivors, with executive function, memory, attention, and processing speed being the most frequently impaired domains. Language impairment, while less studied, is also noted. The review highlights the need for precise identification of factors inducing cognitive impairment in COVID-19 survivors to facilitate early diagnosis and targeted rehabilitation interventions. The findings suggest that cognitive impairment in long-COVID is multifactorial, influenced by factors such as inflammation, sleep disturbances, and sociodemographic characteristics. The review also emphasizes the importance of cultural sensitivity in neuropsychological assessments, given the diverse geographical origins of the included studies. Overall, the evidence supports the widespread occurrence of cognitive impairment in long-COVID, underscoring the need for comprehensive and multidisciplinary evaluations and interventions.