This study investigates whether neurogenesis occurs in the adult human brain, specifically in regions previously identified as neurogenic in adult rodents and monkeys. Using postmortem brain tissue from patients who had been treated with bromodeoxyuridine (BrdU), a thymidine analog that labels DNA during the S phase, the researchers demonstrated that new neurons are generated from dividing progenitor cells in the dentate gyrus of adult humans. The study further indicates that the human hippocampus retains its ability to generate neurons throughout life. The researchers quantified the number of BrdU-positive cells in the granule cell layer, subgranular zone, and hilus, finding that the density of these cells varied between individuals. They also confirmed that these newly generated cells co-express neuronal markers such as NeuN, calbindin, and neuron-specific enolase (NSE), indicating their neuronal phenotype. Additionally, the study found that the subventricular zone of the human caudate nucleus contains progenitor cells that can migrate and differentiate into neurons. These findings suggest that neurogenesis in the human dentate gyrus continues throughout life, providing a basis for further investigation into the potential of human neuroplasticity.This study investigates whether neurogenesis occurs in the adult human brain, specifically in regions previously identified as neurogenic in adult rodents and monkeys. Using postmortem brain tissue from patients who had been treated with bromodeoxyuridine (BrdU), a thymidine analog that labels DNA during the S phase, the researchers demonstrated that new neurons are generated from dividing progenitor cells in the dentate gyrus of adult humans. The study further indicates that the human hippocampus retains its ability to generate neurons throughout life. The researchers quantified the number of BrdU-positive cells in the granule cell layer, subgranular zone, and hilus, finding that the density of these cells varied between individuals. They also confirmed that these newly generated cells co-express neuronal markers such as NeuN, calbindin, and neuron-specific enolase (NSE), indicating their neuronal phenotype. Additionally, the study found that the subventricular zone of the human caudate nucleus contains progenitor cells that can migrate and differentiate into neurons. These findings suggest that neurogenesis in the human dentate gyrus continues throughout life, providing a basis for further investigation into the potential of human neuroplasticity.