Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study

Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study

June 25, 2020 | Aravinthan Varatharaj, Naomi Thomas, Mark A Ellul, Nicholas WS Davies, Thomas A Pollak, Elizabeth L Tenorio, Mustafa Sultan, Ava Easton, Gerome Breen, Michael Zandi, Jonathan P Coles, Hadi Manji, Rustam Al-Shahi Salman, David K Menon, Timothy R Nicholson, Laura A Benjamin, Alan Carson, Craig Smith, Martin R Turner, Tom Solomon, Rachel Kneen, Sarah L Pett, Ian Galea*, Rhys H Thomas*, Benedict D Michael*
Elsevier created a COVID-19 resource centre in January 2020, offering free English and Mandarin information on the virus. The centre is hosted on Elsevier Connect, and the company grants permission for free access to its research in PubMed Central and other repositories for unrestricted reuse. A UK-wide study, "Neurological and neuropsychiatric complications of COVID-19 in 153 patients," investigated the impact of the virus on the brain and mental health. The study involved neurology, psychiatry, stroke, and intensive care professionals across the UK. Data were collected through secure case report portals, with 153 cases meeting clinical definitions. The median age was 71 years, with 77 cases involving cerebrovascular events, including ischaemic strokes. Altered mental status was common, with 39 cases involving encephalopathy or encephalitis, and 23 cases classified as psychiatric diagnoses. Neuropsychiatric disorders included new-onset psychosis, neurocognitive syndromes, and affective disorders. The study highlights the first nationwide surveillance of acute neurological and psychiatric complications of COVID-19. Altered mental status was the second most common presentation, often in younger patients. The findings provide critical data for clinicians, researchers, and funders to guide future research and health policy. The study emphasizes the importance of interdisciplinary collaboration in understanding the neurological and psychiatric impacts of the virus. It underscores the need for further research into viral neurotropism, host immune responses, and genetic factors. The study also notes the importance of data sharing and collaboration across countries to better understand and manage the pandemic's effects on the brain and mental health.Elsevier created a COVID-19 resource centre in January 2020, offering free English and Mandarin information on the virus. The centre is hosted on Elsevier Connect, and the company grants permission for free access to its research in PubMed Central and other repositories for unrestricted reuse. A UK-wide study, "Neurological and neuropsychiatric complications of COVID-19 in 153 patients," investigated the impact of the virus on the brain and mental health. The study involved neurology, psychiatry, stroke, and intensive care professionals across the UK. Data were collected through secure case report portals, with 153 cases meeting clinical definitions. The median age was 71 years, with 77 cases involving cerebrovascular events, including ischaemic strokes. Altered mental status was common, with 39 cases involving encephalopathy or encephalitis, and 23 cases classified as psychiatric diagnoses. Neuropsychiatric disorders included new-onset psychosis, neurocognitive syndromes, and affective disorders. The study highlights the first nationwide surveillance of acute neurological and psychiatric complications of COVID-19. Altered mental status was the second most common presentation, often in younger patients. The findings provide critical data for clinicians, researchers, and funders to guide future research and health policy. The study emphasizes the importance of interdisciplinary collaboration in understanding the neurological and psychiatric impacts of the virus. It underscores the need for further research into viral neurotropism, host immune responses, and genetic factors. The study also notes the importance of data sharing and collaboration across countries to better understand and manage the pandemic's effects on the brain and mental health.
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