The article presents a comprehensive study on neurological and neuropsychiatric complications of COVID-19 in 153 patients across the UK. The study, conducted through an online network of secure rapid-response case report notification portals, aimed to investigate the breadth of complications affecting the brain. Key findings include: - **Background**: Concerns about neurological complications of COVID-19 are growing, but larger studies have been limited by geography and specialty. - **Methods**: The study utilized portals from the Association of British Neurologists (ABN), British Association of Stroke Physicians (BASP), and Royal College of Psychiatrists (RCPsych) to collect data on cerebrovascular events, altered mental status, peripheral neurology, and other presentations. - **Findings**: During the exponential phase of the pandemic, 153 unique cases were reported, with a median patient age of 71 years. Cerebrovascular events were the most common, followed by altered mental status, which included both neurological and psychiatric diagnoses. Younger patients were disproportionately represented among those with altered mental status. - **Interpretation**: This is the first nationwide, cross-specialty surveillance study of acute neurological and psychiatric complications of COVID-19. The findings highlight the importance of interdisciplinary collaboration in clinical neurosciences and provide valuable data for immediate research and health policy planning. The study emphasizes the need for further research to understand the mechanisms underlying these complications and to develop appropriate clinical management strategies.The article presents a comprehensive study on neurological and neuropsychiatric complications of COVID-19 in 153 patients across the UK. The study, conducted through an online network of secure rapid-response case report notification portals, aimed to investigate the breadth of complications affecting the brain. Key findings include: - **Background**: Concerns about neurological complications of COVID-19 are growing, but larger studies have been limited by geography and specialty. - **Methods**: The study utilized portals from the Association of British Neurologists (ABN), British Association of Stroke Physicians (BASP), and Royal College of Psychiatrists (RCPsych) to collect data on cerebrovascular events, altered mental status, peripheral neurology, and other presentations. - **Findings**: During the exponential phase of the pandemic, 153 unique cases were reported, with a median patient age of 71 years. Cerebrovascular events were the most common, followed by altered mental status, which included both neurological and psychiatric diagnoses. Younger patients were disproportionately represented among those with altered mental status. - **Interpretation**: This is the first nationwide, cross-specialty surveillance study of acute neurological and psychiatric complications of COVID-19. The findings highlight the importance of interdisciplinary collaboration in clinical neurosciences and provide valuable data for immediate research and health policy planning. The study emphasizes the need for further research to understand the mechanisms underlying these complications and to develop appropriate clinical management strategies.