Elsevier created a COVID-19 resource centre in 2020 to provide free information on the virus. The centre grants permission for free access to research in PubMed Central and other repositories. A study investigated the neuropathology of 43 patients who died from COVID-19 in Germany, examining brain tissue for glial responses, inflammation, and SARS-CoV-2 presence. The study found that 53% of patients had SARS-CoV-2 in their brains, with viral proteins detected in cranial nerves and isolated brainstem cells. However, SARS-CoV-2 presence was not linked to severe neuropathological changes. The brain showed mild neuropathological changes, with pronounced neuroinflammation in the brainstem. The study suggests that CNS damage may not be directly caused by SARS-CoV-2, but rather by immune responses. The findings highlight the need for further research to understand how SARS-CoV-2 gains access to the brain and the role of immune responses in neurological symptoms. The study was funded by the German Research Foundation and other organizations. The results indicate that while SARS-CoV-2 can be present in the brain, it does not necessarily cause severe neurological damage. The study's limitations include a small sample size and lack of age- and sex-matched controls. The findings contribute to the understanding of neurological complications in COVID-19 patients.Elsevier created a COVID-19 resource centre in 2020 to provide free information on the virus. The centre grants permission for free access to research in PubMed Central and other repositories. A study investigated the neuropathology of 43 patients who died from COVID-19 in Germany, examining brain tissue for glial responses, inflammation, and SARS-CoV-2 presence. The study found that 53% of patients had SARS-CoV-2 in their brains, with viral proteins detected in cranial nerves and isolated brainstem cells. However, SARS-CoV-2 presence was not linked to severe neuropathological changes. The brain showed mild neuropathological changes, with pronounced neuroinflammation in the brainstem. The study suggests that CNS damage may not be directly caused by SARS-CoV-2, but rather by immune responses. The findings highlight the need for further research to understand how SARS-CoV-2 gains access to the brain and the role of immune responses in neurological symptoms. The study was funded by the German Research Foundation and other organizations. The results indicate that while SARS-CoV-2 can be present in the brain, it does not necessarily cause severe neurological damage. The study's limitations include a small sample size and lack of age- and sex-matched controls. The findings contribute to the understanding of neurological complications in COVID-19 patients.